Patient characteristics at SMM diagnosis stratified by FLCr ≥100 or <100 and BMPC ≥60 or <60
| Variables . | All patients . | FLCr <100 . | FLCr >100 . | P . | BMPC <60 . | BMPC >60 . | P . |
|---|---|---|---|---|---|---|---|
| Patients, n | 273 | 156 | 27 | — | 251 | 22 | — |
| Median age (range), y | 60 (20-90) | 60 (25-82) | 62 (33-75) | .93 | 60 (20-90) | 60 (36-77) | .82 |
| Male sex | 143/273 (52) | 80/156 (51) | 16/27 (59) | .77 | 130/251 (52) | 13/22 (59) | .51 |
| BMPC | |||||||
| Median (range), % | 20 (10-95) | 20 (10-80) | 30 (12-90) | .004 | 20 (10-50) | 70 (60-95) | <.0001 |
| Median %, if <60% | 20 | 20 | 22 | .02 | — | — | — |
| 10%-60% | 251/273 (92) | 147/156 (94) | 22/27 (81) | .02 | — | — | |
| Isotype | |||||||
| IgG | 196/273 (72) | 103/156 (66) | 21/27 (78) | .10 | 181/251 (72) | 15/22 (68) | .79 |
| IgA | 57/273 (21) | 41/156 (26) | 3/27 (11) | 51/251 (20) | 6/22 (27) | ||
| LC only | 13/273 (5) | 6/156 (4) | 3/27 (11) | 12/251 (5) | 1/22 (5) | ||
| Other (IgM, IgD, biclonal) | 7/273 (3) | 6/156 (4) | 0/27 (0) | 7/251 (3) | 0/22 (0) | ||
| Involved light chain | |||||||
| κ | 192/273 (70) | 108/156 (69) | 21/27 (78) | .64 | 178/251 (71) | 14/22 (64) | .68 |
| Λ | 79/273 (29) | 47/156 (30) | 6/27 (22) | 71/251 (28) | 8/22 (36) | ||
| Biclonal | 2/273 (1) | 1/156 (1) | 0/27 (0) | 2/251 (1) | 0/22 (0) | ||
| Serum monoclonal protein | |||||||
| Median m-protein (range), g/dL | 1.9 (0-5.3) | 1.7 (0.5-3) | 2.2 (0-4.2) | .23 | 1.8 (0-5.3) | 2.8 (0.4-43) | .003 |
| <3 g/dL | 189/220 (86) | 124/156 (79) | 20/24 (83) | .84 | 180/204 (8) | 9/16 (56) | .004 |
| ≥3 g/dL | 31/220 (14) | 22/156 (21) | 4/24 (17) | 24/204 (12) | 7/16 (44) | ||
| Free light chain | |||||||
| FLCr <100 | 156/183 (85) | — | — | — | 147/169 (87) | 9/14 (64) | .02 |
| FLCr >100 | 27/183 (15) | — | — | 22/169 (13) | 5/14 (36) | ||
| Median light chain concentration, mg/L | |||||||
| Median difference in involved and uninvolved FLC (range) | 61 (0-2838) | 45 (0-2418) | 532 (28-2838) | <.0001 | 57 (0-2838) | 129 (22-765) | .10 |
| Median κ of involved (range) | 59 (3-2862) | 46 (3-1288) | 633 (28-2862) | <.0001 | 56 (3-2862) | 107 (25-528) | .38 |
| Median Λ of involved (range) | 105 (2-2500) | 80 (2-2499) | 462 (117-1500) | .011 | 85 (2-2500) | 154 (36-769) | .23 |
| FISH risk | |||||||
| Available FISH, n | 149 | 96 | 18 | 138 | 11 | ||
| Normal | 61/149 (41) | 42/96 (43) | 4/18 (22) | .33 | 60/138 (43) | 1/11 (9) | .10 |
| Other risk | 30/149 (20) | 15/96 (16) | 4/18 (22) | 27/138 (20) | 3/11 (27) | ||
| Hyperdiploidy | 33/149 (22) | 20/96 (21) | 4/18 (22) | 28/138 (20) | 5/11 (46) | ||
| t(4;14), del17p, +1q21† | 25/149 (17) | 19/96 (20) | 6/18 (34) | 23/138 (17) | 2/11 (18) | ||
| t(4;14) | 14 (47) | 11 (5) | 3 (30) | 13 (50) | 1 (25) | ||
| del17p | 2 (6) | 1 (5) | 1 (10) | 0 (0) | 2 (50) | ||
| +1q21 | 14 (47) | 8 (40) | 6 (60) | 13 (50) | 1 (25) |
| Variables . | All patients . | FLCr <100 . | FLCr >100 . | P . | BMPC <60 . | BMPC >60 . | P . |
|---|---|---|---|---|---|---|---|
| Patients, n | 273 | 156 | 27 | — | 251 | 22 | — |
| Median age (range), y | 60 (20-90) | 60 (25-82) | 62 (33-75) | .93 | 60 (20-90) | 60 (36-77) | .82 |
| Male sex | 143/273 (52) | 80/156 (51) | 16/27 (59) | .77 | 130/251 (52) | 13/22 (59) | .51 |
| BMPC | |||||||
| Median (range), % | 20 (10-95) | 20 (10-80) | 30 (12-90) | .004 | 20 (10-50) | 70 (60-95) | <.0001 |
| Median %, if <60% | 20 | 20 | 22 | .02 | — | — | — |
| 10%-60% | 251/273 (92) | 147/156 (94) | 22/27 (81) | .02 | — | — | |
| Isotype | |||||||
| IgG | 196/273 (72) | 103/156 (66) | 21/27 (78) | .10 | 181/251 (72) | 15/22 (68) | .79 |
| IgA | 57/273 (21) | 41/156 (26) | 3/27 (11) | 51/251 (20) | 6/22 (27) | ||
| LC only | 13/273 (5) | 6/156 (4) | 3/27 (11) | 12/251 (5) | 1/22 (5) | ||
| Other (IgM, IgD, biclonal) | 7/273 (3) | 6/156 (4) | 0/27 (0) | 7/251 (3) | 0/22 (0) | ||
| Involved light chain | |||||||
| κ | 192/273 (70) | 108/156 (69) | 21/27 (78) | .64 | 178/251 (71) | 14/22 (64) | .68 |
| Λ | 79/273 (29) | 47/156 (30) | 6/27 (22) | 71/251 (28) | 8/22 (36) | ||
| Biclonal | 2/273 (1) | 1/156 (1) | 0/27 (0) | 2/251 (1) | 0/22 (0) | ||
| Serum monoclonal protein | |||||||
| Median m-protein (range), g/dL | 1.9 (0-5.3) | 1.7 (0.5-3) | 2.2 (0-4.2) | .23 | 1.8 (0-5.3) | 2.8 (0.4-43) | .003 |
| <3 g/dL | 189/220 (86) | 124/156 (79) | 20/24 (83) | .84 | 180/204 (8) | 9/16 (56) | .004 |
| ≥3 g/dL | 31/220 (14) | 22/156 (21) | 4/24 (17) | 24/204 (12) | 7/16 (44) | ||
| Free light chain | |||||||
| FLCr <100 | 156/183 (85) | — | — | — | 147/169 (87) | 9/14 (64) | .02 |
| FLCr >100 | 27/183 (15) | — | — | 22/169 (13) | 5/14 (36) | ||
| Median light chain concentration, mg/L | |||||||
| Median difference in involved and uninvolved FLC (range) | 61 (0-2838) | 45 (0-2418) | 532 (28-2838) | <.0001 | 57 (0-2838) | 129 (22-765) | .10 |
| Median κ of involved (range) | 59 (3-2862) | 46 (3-1288) | 633 (28-2862) | <.0001 | 56 (3-2862) | 107 (25-528) | .38 |
| Median Λ of involved (range) | 105 (2-2500) | 80 (2-2499) | 462 (117-1500) | .011 | 85 (2-2500) | 154 (36-769) | .23 |
| FISH risk | |||||||
| Available FISH, n | 149 | 96 | 18 | 138 | 11 | ||
| Normal | 61/149 (41) | 42/96 (43) | 4/18 (22) | .33 | 60/138 (43) | 1/11 (9) | .10 |
| Other risk | 30/149 (20) | 15/96 (16) | 4/18 (22) | 27/138 (20) | 3/11 (27) | ||
| Hyperdiploidy | 33/149 (22) | 20/96 (21) | 4/18 (22) | 28/138 (20) | 5/11 (46) | ||
| t(4;14), del17p, +1q21† | 25/149 (17) | 19/96 (20) | 6/18 (34) | 23/138 (17) | 2/11 (18) | ||
| t(4;14) | 14 (47) | 11 (5) | 3 (30) | 13 (50) | 1 (25) | ||
| del17p | 2 (6) | 1 (5) | 1 (10) | 0 (0) | 2 (50) | ||
| +1q21 | 14 (47) | 8 (40) | 6 (60) | 13 (50) | 1 (25) |
Values are n (%) unless otherwise indicated.
Free light chain values at baseline were only available for 183 patients for free light chain ratio subgroup analysis.
The sum of all high-risk events is greater than the number of patients with high risk as patients may have met multiple high-risk criteria.