LASSO multivariate analysis of the association between clinical variables and GVHD/NRM
| Clinical variable . | OR* . | ||||
|---|---|---|---|---|---|
| aGVHD 2-4 . | aGVHD 3-4 . | cGVHD . | Extensive cGVHD . | NRM . | |
| Recipient sex, female vs male | 0.872 | 0.684 | 0.805 | ||
| Recipient age > median 45 y | 1.095 | 1.043 | 2.122 | ||
| Female donor/male recipient | 1.178 | ||||
| Diagnosis | |||||
| AML | 0.876 | 0.856 | |||
| ALL | |||||
| MDS | 1.204 | 2.244 | |||
| Lymphoma | 1.181 | 1.232 | |||
| Myelofibrosis | 0.490 | ||||
| MM | 0.657 | ||||
| Conditioning, RIC vs MAC | 0.957 | 0.760 | |||
| Conditioning regimen, no TBI vs TBI | 0.838 | 1.311 | |||
| Stem-cell source, PB vs BM | 1.151 | 1.470 | 2.360 | ||
| aGVHD 2-4 | 1.284 | 1.253 | |||
| Clinical variable . | OR* . | ||||
|---|---|---|---|---|---|
| aGVHD 2-4 . | aGVHD 3-4 . | cGVHD . | Extensive cGVHD . | NRM . | |
| Recipient sex, female vs male | 0.872 | 0.684 | 0.805 | ||
| Recipient age > median 45 y | 1.095 | 1.043 | 2.122 | ||
| Female donor/male recipient | 1.178 | ||||
| Diagnosis | |||||
| AML | 0.876 | 0.856 | |||
| ALL | |||||
| MDS | 1.204 | 2.244 | |||
| Lymphoma | 1.181 | 1.232 | |||
| Myelofibrosis | 0.490 | ||||
| MM | 0.657 | ||||
| Conditioning, RIC vs MAC | 0.957 | 0.760 | |||
| Conditioning regimen, no TBI vs TBI | 0.838 | 1.311 | |||
| Stem-cell source, PB vs BM | 1.151 | 1.470 | 2.360 | ||
| aGVHD 2-4 | 1.284 | 1.253 | |||
OR values for the variables selected by the LASSO procedure (described in “Methods”). OR values were obtained with the exponential function of β coefficient, which compares the strength of the effect of each individual independent variable with the dependent variable. The higher the absolute value of β, the stronger the effect. β = 0, OR = 1 (neutral); β < 0, OR < 1 (L); β > 0, OR > 1 (H).