Kinetics of WBC, HHV-6 viral load, and PB host chimerism
. | Days post-HSCT . | WBC count, k/mL . | HHV-6 viral load, ×103 copies/mL WB . | PB chimerism by FISH, XX cells/total cells (% host chimerism) . | HHV-6 viral load (×103 copies/mL WB)/WBC count (k/mL) . |
---|---|---|---|---|---|
Peritransplant period* | −15 | 100 | 559 | 5.59 | |
−9 | 200 | 210 | 1.05 | ||
−1 | 200 | 170 | 0.85 | ||
3 | 400 | 393 | 0.98 | ||
10 | 200 | 216 | 1.08 | ||
Early posttransplant period† | 32 | 3800 | 10/300 (3.3) | ||
98 | 4900 | 131 | 8/200 (4) | 0.027 | |
105 | 6400 | 85 | 7/400 (1.7) | 0.013 | |
126 | 7000 | 150 | 0.021 | ||
133 | 6900 | 4/200 (2) | |||
Late posttransplant period‡ | 290 | 6600 | 0/200 (0) | ||
360 | 5000 | 1.6 | 0/200 (0) | 0.0003 | |
374 | 4000 | 1.4 | 0.0004 | ||
399 | 5100 | <0.5 | <0.0001 | ||
430 | 3900 | 0/200 (0) |
. | Days post-HSCT . | WBC count, k/mL . | HHV-6 viral load, ×103 copies/mL WB . | PB chimerism by FISH, XX cells/total cells (% host chimerism) . | HHV-6 viral load (×103 copies/mL WB)/WBC count (k/mL) . |
---|---|---|---|---|---|
Peritransplant period* | −15 | 100 | 559 | 5.59 | |
−9 | 200 | 210 | 1.05 | ||
−1 | 200 | 170 | 0.85 | ||
3 | 400 | 393 | 0.98 | ||
10 | 200 | 216 | 1.08 | ||
Early posttransplant period† | 32 | 3800 | 10/300 (3.3) | ||
98 | 4900 | 131 | 8/200 (4) | 0.027 | |
105 | 6400 | 85 | 7/400 (1.7) | 0.013 | |
126 | 7000 | 150 | 0.021 | ||
133 | 6900 | 4/200 (2) | |||
Late posttransplant period‡ | 290 | 6600 | 0/200 (0) | ||
360 | 5000 | 1.6 | 0/200 (0) | 0.0003 | |
374 | 4000 | 1.4 | 0.0004 | ||
399 | 5100 | <0.5 | <0.0001 | ||
430 | 3900 | 0/200 (0) |
Peritransplant period is defined as the interval between pretransplant and early post-HSCT before donor myeloid engraftment.
Early posttransplant period is defined as the post-HSCT interval after donor myeloid engraftment and before full donor PB chimerism was established.
Late posttransplant period is defined as the post-HSCT interval after full donor PB chimerism.