Table 1.

Kinetics of WBC, HHV-6 viral load, and PB host chimerism

Days post-HSCTWBC count, k/mLHHV-6 viral load, ×103 copies/mL WBPB chimerism by FISH, XX cells/total cells (% host chimerism)HHV-6 viral load (×103 copies/mL WB)/WBC count (k/mL)
Peritransplant period* −15 100 559  5.59 
−9 200 210  1.05 
−1 200 170  0.85 
400 393  0.98 
10 200 216  1.08 
Early posttransplant period 32 3800  10/300 (3.3)  
98 4900 131 8/200 (4) 0.027 
105 6400 85 7/400 (1.7) 0.013 
126 7000 150  0.021 
133 6900  4/200 (2)  
Late posttransplant period 290 6600  0/200 (0)  
360 5000 1.6 0/200 (0) 0.0003 
374 4000 1.4  0.0004 
399 5100 <0.5  <0.0001 
430 3900  0/200 (0)  
Days post-HSCTWBC count, k/mLHHV-6 viral load, ×103 copies/mL WBPB chimerism by FISH, XX cells/total cells (% host chimerism)HHV-6 viral load (×103 copies/mL WB)/WBC count (k/mL)
Peritransplant period* −15 100 559  5.59 
−9 200 210  1.05 
−1 200 170  0.85 
400 393  0.98 
10 200 216  1.08 
Early posttransplant period 32 3800  10/300 (3.3)  
98 4900 131 8/200 (4) 0.027 
105 6400 85 7/400 (1.7) 0.013 
126 7000 150  0.021 
133 6900  4/200 (2)  
Late posttransplant period 290 6600  0/200 (0)  
360 5000 1.6 0/200 (0) 0.0003 
374 4000 1.4  0.0004 
399 5100 <0.5  <0.0001 
430 3900  0/200 (0)  
*

Peritransplant period is defined as the interval between pretransplant and early post-HSCT before donor myeloid engraftment.

Early posttransplant period is defined as the post-HSCT interval after donor myeloid engraftment and before full donor PB chimerism was established.

Late posttransplant period is defined as the post-HSCT interval after full donor PB chimerism.

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