Multivariable hazard models for EFS and DFS among Ph− B-ALL patients
| . | Univariate . | Final multivariable models . | ||
|---|---|---|---|---|
| . | HR (95% CI) . | P . | HR (95% CI) . | P . |
| EFS (10-y age threshold), N = 385 | ||||
| IKZF1, deleted vs nondeleted | 3.5 (2.1-6.0) | <.001 | 2.8 (1.6-4.6) | <.001 |
| WBC, ≥50 vs <50 × 109/L | 3.9 (2.4-6.6) | <.001 | 3.3 (1.9-5.6) | <.001 |
| EFS (15-y age threshold), N =385 | ||||
| IKZF1, deleted vs nondeleted | 3.5 (2.1-6.0) | <.001 | 2.2 (1.2-3.9) | .011 |
| Age, ≥15 y vs <15 y | 4.6 (2.5-8.8) | <.001 | 2.8 (1.4-5.7) | .003 |
| WBC, ≥50 vs <50 × 109/L | 3.9 (2.4-6.6) | <.001 | 3.1 (1.8-5.3) | <.001 |
| DFS, N = 526*† | ||||
| MRD, ≥10−3 vs <10−3 | 3.0 (1.5-5.8) | .001 | 2.9 (1.5-5.7) | .002 |
| KMT2A, rearranged vs not rearranged | 6.0 (1.9-19.3) | .003 | 4.3 (1.3-14.8) | .019 |
| iAMP21, present vs not present | 4.3 (1.6-12.1) | .005 | 5.3 (1.9-14.8) | .002 |
| WBC, ≥50 vs <50 × 109/L | 2.3 (1.2-4.2) | .011 | 1.9 (1.0-3.7) | .054 |
| DFS (10−3MRD threshold), N = 316*‡ | ||||
| IKZF1, deleted vs nondeleted | 3.1 (1.6-6.4) | .001 | 2.7 (1.3-5.6) | .005 |
| WBC, ≥50 vs <50 × 109/L | 2.5 (1.3-5.0) | .008 | 2.1 (1.0-4.2) | .036 |
| DFS (10−4MRD threshold), N = 306*§ | ||||
| IKZF1, deleted vs nondeleted | 2.9 (1.4-5.8) | .004 | 2.1 (1.0-4.4) | .050 |
| WBC, ≥50 vs <50 × 109/L | 2.7 (1.4-5.4) | .004 | 2.1 (1.0-4.2) | .042 |
| MRD, ≥10−4 vs <10−4 | 3.4 (1.7-6.6) | <.001 | 2.9 (1.5-5.7) | .002 |
| . | Univariate . | Final multivariable models . | ||
|---|---|---|---|---|
| . | HR (95% CI) . | P . | HR (95% CI) . | P . |
| EFS (10-y age threshold), N = 385 | ||||
| IKZF1, deleted vs nondeleted | 3.5 (2.1-6.0) | <.001 | 2.8 (1.6-4.6) | <.001 |
| WBC, ≥50 vs <50 × 109/L | 3.9 (2.4-6.6) | <.001 | 3.3 (1.9-5.6) | <.001 |
| EFS (15-y age threshold), N =385 | ||||
| IKZF1, deleted vs nondeleted | 3.5 (2.1-6.0) | <.001 | 2.2 (1.2-3.9) | .011 |
| Age, ≥15 y vs <15 y | 4.6 (2.5-8.8) | <.001 | 2.8 (1.4-5.7) | .003 |
| WBC, ≥50 vs <50 × 109/L | 3.9 (2.4-6.6) | <.001 | 3.1 (1.8-5.3) | <.001 |
| DFS, N = 526*† | ||||
| MRD, ≥10−3 vs <10−3 | 3.0 (1.5-5.8) | .001 | 2.9 (1.5-5.7) | .002 |
| KMT2A, rearranged vs not rearranged | 6.0 (1.9-19.3) | .003 | 4.3 (1.3-14.8) | .019 |
| iAMP21, present vs not present | 4.3 (1.6-12.1) | .005 | 5.3 (1.9-14.8) | .002 |
| WBC, ≥50 vs <50 × 109/L | 2.3 (1.2-4.2) | .011 | 1.9 (1.0-3.7) | .054 |
| DFS (10−3MRD threshold), N = 316*‡ | ||||
| IKZF1, deleted vs nondeleted | 3.1 (1.6-6.4) | .001 | 2.7 (1.3-5.6) | .005 |
| WBC, ≥50 vs <50 × 109/L | 2.5 (1.3-5.0) | .008 | 2.1 (1.0-4.2) | .036 |
| DFS (10−4MRD threshold), N = 306*§ | ||||
| IKZF1, deleted vs nondeleted | 2.9 (1.4-5.8) | .004 | 2.1 (1.0-4.4) | .050 |
| WBC, ≥50 vs <50 × 109/L | 2.7 (1.4-5.4) | .004 | 2.1 (1.0-4.2) | .042 |
| MRD, ≥10−4 vs <10−4 | 3.4 (1.7-6.6) | <.001 | 2.9 (1.5-5.7) | .002 |
Final multivariable model results are displayed, with only statistically significant factors presented. All multivariable models were adjusted for baseline characteristics, cytogenetic findings, and end-induction MRD (in DFS models) as detailed in the “Patients and methods” section.
HR, hazard ratio.
Age was considered with a 10 y and 15 y of age threshold in each DFS model, with the same final model suggested with either threshold.
IKZF1 deletion status not considered in this model (considered in all other models).
Does not include indeterminate MRD.
Does not include indeterminate MRD and required detailed quantitative MRD results.