Table 1. Treatment in CALGB 10404 Time *... | American Society of Hematology

Table 1.

Treatment in CALGB 10404

Time*	Arm A: FR	Arm B: FR+L	Arm C: FCR	Arm D: FCR+L
Month 1	Fludarabine 25 mg/m² IV days 1-5	Fludarabine 25 mg/m² IV days 1-5	Fludarabine 25 mg/m² IV days 1-3†	NA
	Rituximab 50 mg/m² IVPB day 1	Rituximab 50 mg/m² IVPB day 1	Cyclophosphamide 250 mg/m² days 1-3†
	Rituximab 325 mg/m² IVPB day 3	Rituximab 325 mg/m² IVPB day 3	Rituximab 50 mg/m² IVPB day 1
	Rituximab 375 mg/m² IVPB day 5	Rituximab 375 mg/m² IVPB day 5	Rituximab 325 mg/m² IVPB day 2
Months 2-6	Fludarabine 25 mg/m² IV days 1-5	Fludarabine 25 mg/m² IV days 1-5	Fludarabine 25 mg/m² IV days 1-3†	Fludarabine 25 mg/m² IV days 1-3†
	Rituximab 375 mg/m² IVPB day 1	Rituximab 375 mg/m² IVPB day 1	Cyclophosphamide 250 mg/m² days 1-3†	Cyclophosphamide 250 mg/m² days 1-3†
	Rituximab 375 mg/m² IVPB day 1	Rituximab 375 mg/m² IVPB day 1	Rituximab 500 mg/m² IVPB day 1	Rituximab 500 mg/m² IVPB day 1
End of 9 mo	Full staging	Full staging	Full staging	Full staging
Month 10	NA	Lenalidomide 5 mg by mouth days 1-21	NA	Lenalidomide 5 mg by mouth days 1-21
Months 11-15	NA	Lenalidomide 10 mg by mouth days 1-21	NA	Lenalidomide 10 mg by mouth days 1-21
End of 18 mo	NA	Full staging	NA	Full staging
End of 24 mo	Full staging	Full staging	Full staging	Full staging

Time*	Arm A: FR	Arm B: FR+L	Arm C: FCR	Arm D: FCR+L
Month 1	Fludarabine 25 mg/m² IV days 1-5	Fludarabine 25 mg/m² IV days 1-5	Fludarabine 25 mg/m² IV days 1-3†	NA
	Rituximab 50 mg/m² IVPB day 1	Rituximab 50 mg/m² IVPB day 1	Cyclophosphamide 250 mg/m² days 1-3†
	Rituximab 325 mg/m² IVPB day 3	Rituximab 325 mg/m² IVPB day 3	Rituximab 50 mg/m² IVPB day 1
	Rituximab 375 mg/m² IVPB day 5	Rituximab 375 mg/m² IVPB day 5	Rituximab 325 mg/m² IVPB day 2
Months 2-6	Fludarabine 25 mg/m² IV days 1-5	Fludarabine 25 mg/m² IV days 1-5	Fludarabine 25 mg/m² IV days 1-3†	Fludarabine 25 mg/m² IV days 1-3†
	Rituximab 375 mg/m² IVPB day 1	Rituximab 375 mg/m² IVPB day 1	Cyclophosphamide 250 mg/m² days 1-3†	Cyclophosphamide 250 mg/m² days 1-3†
	Rituximab 375 mg/m² IVPB day 1	Rituximab 375 mg/m² IVPB day 1	Rituximab 500 mg/m² IVPB day 1	Rituximab 500 mg/m² IVPB day 1
End of 9 mo	Full staging	Full staging	Full staging	Full staging
Month 10	NA	Lenalidomide 5 mg by mouth days 1-21	NA	Lenalidomide 5 mg by mouth days 1-21
Months 11-15	NA	Lenalidomide 10 mg by mouth days 1-21	NA	Lenalidomide 10 mg by mouth days 1-21
End of 18 mo	NA	Full staging	NA	Full staging
End of 24 mo	Full staging	Full staging	Full staging	Full staging

Patients with del(11q) disease initially randomized to arms A or B were reassigned to arm D after the first month.

IVPB, IV piggyback; NA, not applicable.

Each cycle of therapy was 28 days.

Patients 70 years of age and older received fludarabine 20 mg/m² and cyclophosphamide 150 mg/m².