Table 2.

Treatment comparisons for pulmonary function and hand-grip strength

VariablesVitamin D3 100 000 IU/moVitamin D3 12 000 IU/moP for interaction between treatment group and time
Pulmonary function tests 
 FVC, % predicted n = 28 n = 30 0.52 
  Baseline 85.5 ± 2.8 90.2 ± 2.3 
  Treatment year 1 85.2 ± 2.7 92.4 ± 2.3 
  Treatment year 2 85.0 ± 2.5 92.1 ± 2.5 
 FEV1, % predicted n = 28 n = 30 0.81 
  Baseline 80.4 ± 2.4 84.9 ± 2.3 
  Treatment year 1 79.1 ± 2.7 85.3 ± 2.1 
  Treatment year 2 78.9 ± 2.8 84.5 ± 2.0 
 FEV1/FVC ratio, % n = 28 n = 30 0.95 
  Baseline 84.0 ± 1.5 83.3 ± 1.5 
  Treatment year 1 82.6 ± 1.0 81.7 ± 1.3 
  Treatment year 2 82.2 ± 1.5 81.6 ± 1.2 
 FEF25-75, % predicted n = 28 n = 30 0.87 
  Baseline 69.8 ± 5.2 68.8 ± 4.9 
  Treatment year 1 62.9 ± 4.4 64.8 ± 4.3 
  Treatment year 2 62.8 ± 4.4 65.6 ± 4.3 
 RV/TLC ratio, % n = 23 n = 20 0.96 
  Baseline 26.9 ± 1.3 25.1 ± 1.6 
  Treatment year 1 25.4 ± 1.8 22.6 ± 1.9 
  Treatment year 2 22.8 ± 1.6 21.8 ± 1.9 
 DLCO, % predicted n = 20 n = 19 0.69 
  Baseline 68.0 ± 3.2 72.3 ± 3.9 
  Treatment year 1 62.9 ± 3.2 67.8 ± 2.4 
  Treatment year 2 68.1 ± 3.8 72.9 ± 2.9 
 FENO, ppb n = 28 n = 30 0.54 
  Baseline 19.3 ± 2.7 16.9 ± 2.1 
  Treatment year 1 20.5 ± 3.5 16.1 ± 2.1 
  Treatment year 2 18.1 ± 2.7 16.4 ± 2.4 
 MIP, cm H2O n = 23 n = 19 1.00 
  Baseline 69.1 ± 5.6 59.9 ± 5.3 
  Treatment year 1 78.7 ± 6.1 80.4 ± 6.3 
  Treatment year 2 77.4 ± 5.0 74.6 ± 4.7 
 MEP, cm H2O n = 23 n = 19 0.70 
  Baseline 66.3 ± 3.9 66.3 ± 5.4 
  Treatment year 1 60.4 ± 3.3 57.3 ± 3.1 
  Treatment year 2 58.7 ± 3.4 56.2 ± 4.0 
Hand-grip strength 
 Right hand, pounds force n = 25 n = 27 0.81 
  Baseline 21.2 ± 3.2 16.9 ± 2.2 
  Treatment year 1 20.6 ± 3.0 16.6 ± 2.4 
  Treatment year 2 23.8 ± 4.1 17.4 ± 2.9 
 Left hand, pounds force n = 25 n = 27 0.97 
  Baseline 19.9 ± 3.4 16.0 ± 2.1 
  Treatment year 1 19.0 ± 3.4 13.6 ± 2.4 
  Treatment year 2 19.6 ± 3.6 15.8 ± 2.8 
 Dominant hand, pounds force n = 25 n = 27 0.24 
  Baseline 21.2 ± 3.2 17.1 ± 2.2 
  Treatment year 1 20.8 ± 3.0 17.3 ± 2.4 
  Treatment year 2 23.8 ± 4.1 18.1 ± 3.1 
VariablesVitamin D3 100 000 IU/moVitamin D3 12 000 IU/moP for interaction between treatment group and time
Pulmonary function tests 
 FVC, % predicted n = 28 n = 30 0.52 
  Baseline 85.5 ± 2.8 90.2 ± 2.3 
  Treatment year 1 85.2 ± 2.7 92.4 ± 2.3 
  Treatment year 2 85.0 ± 2.5 92.1 ± 2.5 
 FEV1, % predicted n = 28 n = 30 0.81 
  Baseline 80.4 ± 2.4 84.9 ± 2.3 
  Treatment year 1 79.1 ± 2.7 85.3 ± 2.1 
  Treatment year 2 78.9 ± 2.8 84.5 ± 2.0 
 FEV1/FVC ratio, % n = 28 n = 30 0.95 
  Baseline 84.0 ± 1.5 83.3 ± 1.5 
  Treatment year 1 82.6 ± 1.0 81.7 ± 1.3 
  Treatment year 2 82.2 ± 1.5 81.6 ± 1.2 
 FEF25-75, % predicted n = 28 n = 30 0.87 
  Baseline 69.8 ± 5.2 68.8 ± 4.9 
  Treatment year 1 62.9 ± 4.4 64.8 ± 4.3 
  Treatment year 2 62.8 ± 4.4 65.6 ± 4.3 
 RV/TLC ratio, % n = 23 n = 20 0.96 
  Baseline 26.9 ± 1.3 25.1 ± 1.6 
  Treatment year 1 25.4 ± 1.8 22.6 ± 1.9 
  Treatment year 2 22.8 ± 1.6 21.8 ± 1.9 
 DLCO, % predicted n = 20 n = 19 0.69 
  Baseline 68.0 ± 3.2 72.3 ± 3.9 
  Treatment year 1 62.9 ± 3.2 67.8 ± 2.4 
  Treatment year 2 68.1 ± 3.8 72.9 ± 2.9 
 FENO, ppb n = 28 n = 30 0.54 
  Baseline 19.3 ± 2.7 16.9 ± 2.1 
  Treatment year 1 20.5 ± 3.5 16.1 ± 2.1 
  Treatment year 2 18.1 ± 2.7 16.4 ± 2.4 
 MIP, cm H2O n = 23 n = 19 1.00 
  Baseline 69.1 ± 5.6 59.9 ± 5.3 
  Treatment year 1 78.7 ± 6.1 80.4 ± 6.3 
  Treatment year 2 77.4 ± 5.0 74.6 ± 4.7 
 MEP, cm H2O n = 23 n = 19 0.70 
  Baseline 66.3 ± 3.9 66.3 ± 5.4 
  Treatment year 1 60.4 ± 3.3 57.3 ± 3.1 
  Treatment year 2 58.7 ± 3.4 56.2 ± 4.0 
Hand-grip strength 
 Right hand, pounds force n = 25 n = 27 0.81 
  Baseline 21.2 ± 3.2 16.9 ± 2.2 
  Treatment year 1 20.6 ± 3.0 16.6 ± 2.4 
  Treatment year 2 23.8 ± 4.1 17.4 ± 2.9 
 Left hand, pounds force n = 25 n = 27 0.97 
  Baseline 19.9 ± 3.4 16.0 ± 2.1 
  Treatment year 1 19.0 ± 3.4 13.6 ± 2.4 
  Treatment year 2 19.6 ± 3.6 15.8 ± 2.8 
 Dominant hand, pounds force n = 25 n = 27 0.24 
  Baseline 21.2 ± 3.2 17.1 ± 2.2 
  Treatment year 1 20.8 ± 3.0 17.3 ± 2.4 
  Treatment year 2 23.8 ± 4.1 18.1 ± 3.1 

All data are mean ± SEM.

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