Table 2. Treatment comparisons for... | American Society of Hematology

Table 2.

Treatment comparisons for pulmonary function and hand-grip strength

Variables	Vitamin D₃ 100 000 IU/mo	Vitamin D₃ 12 000 IU/mo	P for interaction between treatment group and time
Pulmonary function tests
FVC, % predicted	n = 28	n = 30	0.52
Baseline	85.5 ± 2.8	90.2 ± 2.3
Treatment year 1	85.2 ± 2.7	92.4 ± 2.3
Treatment year 2	85.0 ± 2.5	92.1 ± 2.5
FEV₁, % predicted	n = 28	n = 30	0.81
Baseline	80.4 ± 2.4	84.9 ± 2.3
Treatment year 1	79.1 ± 2.7	85.3 ± 2.1
Treatment year 2	78.9 ± 2.8	84.5 ± 2.0
FEV₁/FVC ratio, %	n = 28	n = 30	0.95
Baseline	84.0 ± 1.5	83.3 ± 1.5
Treatment year 1	82.6 ± 1.0	81.7 ± 1.3
Treatment year 2	82.2 ± 1.5	81.6 ± 1.2
FEF_25-75, % predicted	n = 28	n = 30	0.87
Baseline	69.8 ± 5.2	68.8 ± 4.9
Treatment year 1	62.9 ± 4.4	64.8 ± 4.3
Treatment year 2	62.8 ± 4.4	65.6 ± 4.3
RV/TLC ratio, %	n = 23	n = 20	0.96
Baseline	26.9 ± 1.3	25.1 ± 1.6
Treatment year 1	25.4 ± 1.8	22.6 ± 1.9
Treatment year 2	22.8 ± 1.6	21.8 ± 1.9
DLCO, % predicted	n = 20	n = 19	0.69
Baseline	68.0 ± 3.2	72.3 ± 3.9
Treatment year 1	62.9 ± 3.2	67.8 ± 2.4
Treatment year 2	68.1 ± 3.8	72.9 ± 2.9
FENO, ppb	n = 28	n = 30	0.54
Baseline	19.3 ± 2.7	16.9 ± 2.1
Treatment year 1	20.5 ± 3.5	16.1 ± 2.1
Treatment year 2	18.1 ± 2.7	16.4 ± 2.4
MIP, cm H₂O	n = 23	n = 19	1.00
Baseline	69.1 ± 5.6	59.9 ± 5.3
Treatment year 1	78.7 ± 6.1	80.4 ± 6.3
Treatment year 2	77.4 ± 5.0	74.6 ± 4.7
MEP, cm H₂O	n = 23	n = 19	0.70
Baseline	66.3 ± 3.9	66.3 ± 5.4
Treatment year 1	60.4 ± 3.3	57.3 ± 3.1
Treatment year 2	58.7 ± 3.4	56.2 ± 4.0
Hand-grip strength
Right hand, pounds force	n = 25	n = 27	0.81
Baseline	21.2 ± 3.2	16.9 ± 2.2
Treatment year 1	20.6 ± 3.0	16.6 ± 2.4
Treatment year 2	23.8 ± 4.1	17.4 ± 2.9
Left hand, pounds force	n = 25	n = 27	0.97
Baseline	19.9 ± 3.4	16.0 ± 2.1
Treatment year 1	19.0 ± 3.4	13.6 ± 2.4
Treatment year 2	19.6 ± 3.6	15.8 ± 2.8
Dominant hand, pounds force	n = 25	n = 27	0.24
Baseline	21.2 ± 3.2	17.1 ± 2.2
Treatment year 1	20.8 ± 3.0	17.3 ± 2.4
Treatment year 2	23.8 ± 4.1	18.1 ± 3.1

Variables	Vitamin D₃ 100 000 IU/mo	Vitamin D₃ 12 000 IU/mo	P for interaction between treatment group and time
Pulmonary function tests
FVC, % predicted	n = 28	n = 30	0.52
Baseline	85.5 ± 2.8	90.2 ± 2.3
Treatment year 1	85.2 ± 2.7	92.4 ± 2.3
Treatment year 2	85.0 ± 2.5	92.1 ± 2.5
FEV₁, % predicted	n = 28	n = 30	0.81
Baseline	80.4 ± 2.4	84.9 ± 2.3
Treatment year 1	79.1 ± 2.7	85.3 ± 2.1
Treatment year 2	78.9 ± 2.8	84.5 ± 2.0
FEV₁/FVC ratio, %	n = 28	n = 30	0.95
Baseline	84.0 ± 1.5	83.3 ± 1.5
Treatment year 1	82.6 ± 1.0	81.7 ± 1.3
Treatment year 2	82.2 ± 1.5	81.6 ± 1.2
FEF_25-75, % predicted	n = 28	n = 30	0.87
Baseline	69.8 ± 5.2	68.8 ± 4.9
Treatment year 1	62.9 ± 4.4	64.8 ± 4.3
Treatment year 2	62.8 ± 4.4	65.6 ± 4.3
RV/TLC ratio, %	n = 23	n = 20	0.96
Baseline	26.9 ± 1.3	25.1 ± 1.6
Treatment year 1	25.4 ± 1.8	22.6 ± 1.9
Treatment year 2	22.8 ± 1.6	21.8 ± 1.9
DLCO, % predicted	n = 20	n = 19	0.69
Baseline	68.0 ± 3.2	72.3 ± 3.9
Treatment year 1	62.9 ± 3.2	67.8 ± 2.4
Treatment year 2	68.1 ± 3.8	72.9 ± 2.9
FENO, ppb	n = 28	n = 30	0.54
Baseline	19.3 ± 2.7	16.9 ± 2.1
Treatment year 1	20.5 ± 3.5	16.1 ± 2.1
Treatment year 2	18.1 ± 2.7	16.4 ± 2.4
MIP, cm H₂O	n = 23	n = 19	1.00
Baseline	69.1 ± 5.6	59.9 ± 5.3
Treatment year 1	78.7 ± 6.1	80.4 ± 6.3
Treatment year 2	77.4 ± 5.0	74.6 ± 4.7
MEP, cm H₂O	n = 23	n = 19	0.70
Baseline	66.3 ± 3.9	66.3 ± 5.4
Treatment year 1	60.4 ± 3.3	57.3 ± 3.1
Treatment year 2	58.7 ± 3.4	56.2 ± 4.0
Hand-grip strength
Right hand, pounds force	n = 25	n = 27	0.81
Baseline	21.2 ± 3.2	16.9 ± 2.2
Treatment year 1	20.6 ± 3.0	16.6 ± 2.4
Treatment year 2	23.8 ± 4.1	17.4 ± 2.9
Left hand, pounds force	n = 25	n = 27	0.97
Baseline	19.9 ± 3.4	16.0 ± 2.1
Treatment year 1	19.0 ± 3.4	13.6 ± 2.4
Treatment year 2	19.6 ± 3.6	15.8 ± 2.8
Dominant hand, pounds force	n = 25	n = 27	0.24
Baseline	21.2 ± 3.2	17.1 ± 2.2
Treatment year 1	20.8 ± 3.0	17.3 ± 2.4
Treatment year 2	23.8 ± 4.1	18.1 ± 3.1

All data are mean ± SEM.

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