Pathological features of leukemias arising in mice transplanted with rearranged cells
| Mouse number . | Injected cells . | Latency, d . | BM hCD45, % . | BM hCD34, % . | SP hCD45, % . | LV hCD45, % . | PB hCD45, % . | SP wt, mg . | LV wt, mg . | Secondary transplant . |
|---|---|---|---|---|---|---|---|---|---|---|
| S1-AML1 | S1 | 259 | 92.4 | 53.8 | ND | ND | ND | 44.0 | ND | ND |
| S1-AML2 | S1 | 335 | 82.5 | 30.2 | 9.5 | ND | ND | 61.6 | 865.0 | 1/2 |
| S1-AML3 | S1 | 386 | 93.3 | 51.6 | 14.27 | 15.9 | ND | 55.6 | 1331.8 | ND |
| S1-AML4 | S1 | 367 | 98.7 | 19.3 | 22.79 | 17.8 | 8.88 | 114.3 | 1380.9 | 2/2 |
| S1-AML5 | S1 | 331 | 94.72 | 18.1 | 52.2 | 7.9 | 18.6 | 80.8 | 1035.2 | 2/2 |
| S1-AML6 | S1 | 261 | 84.24 | 10.9 | ND | ∼1.0 | ND | 60 | 3460 | ND |
| S2-AML1 | S2 | 265 | 94.6 | 34.7 | 10.2 | ND | ND | 96.0 | 1140 | 3/3 |
| S2-AML2 | S2 | 272 | 87.4 | 43.7 | 3.0 | 0.4 | ND | 23.6 | 581.6 | 1/2 |
| S2-AML3 | S2 | 336 | 66.5 | 15.6 | 1.9 | 0.5 | ND | 75.8 | 2367 | 2/2 |
| S2-AML4 | S2 | 423 | 54.9 | 34.9 | ND | ND | ND | 27.7 | ND | ND |
| Mouse number . | Injected cells . | Latency, d . | BM hCD45, % . | BM hCD34, % . | SP hCD45, % . | LV hCD45, % . | PB hCD45, % . | SP wt, mg . | LV wt, mg . | Secondary transplant . |
|---|---|---|---|---|---|---|---|---|---|---|
| S1-AML1 | S1 | 259 | 92.4 | 53.8 | ND | ND | ND | 44.0 | ND | ND |
| S1-AML2 | S1 | 335 | 82.5 | 30.2 | 9.5 | ND | ND | 61.6 | 865.0 | 1/2 |
| S1-AML3 | S1 | 386 | 93.3 | 51.6 | 14.27 | 15.9 | ND | 55.6 | 1331.8 | ND |
| S1-AML4 | S1 | 367 | 98.7 | 19.3 | 22.79 | 17.8 | 8.88 | 114.3 | 1380.9 | 2/2 |
| S1-AML5 | S1 | 331 | 94.72 | 18.1 | 52.2 | 7.9 | 18.6 | 80.8 | 1035.2 | 2/2 |
| S1-AML6 | S1 | 261 | 84.24 | 10.9 | ND | ∼1.0 | ND | 60 | 3460 | ND |
| S2-AML1 | S2 | 265 | 94.6 | 34.7 | 10.2 | ND | ND | 96.0 | 1140 | 3/3 |
| S2-AML2 | S2 | 272 | 87.4 | 43.7 | 3.0 | 0.4 | ND | 23.6 | 581.6 | 1/2 |
| S2-AML3 | S2 | 336 | 66.5 | 15.6 | 1.9 | 0.5 | ND | 75.8 | 2367 | 2/2 |
| S2-AML4 | S2 | 423 | 54.9 | 34.9 | ND | ND | ND | 27.7 | ND | ND |
h, human; LV, liver; ND, not determined; SP, spleen; wt, weight.