Genotype distributions of intercrosses between double heterozygous mice and crosses between Mcfd2−/−Lman1+/gt1 and Mcfd2+/−Lman1+/gt1 mice
| Crosses . | Genotype distribution . | P . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mcfd2+/−Lman1+/gt1 × Mcfd2+/−Lman1+/gt1 | M−/−,Lgt1/gt1 | M+/−,Lgt1/gt1 | M+/+,Lgt1/gt1 | M−/−,L+/gt1 | M+/−,L+/gt1 | M+/+,L+/gt1 | M−/−,L+/+ | M+/−,L+/+ | M+/+,L+/+ | |
| Expected, % | 6.25 | 12.5 | 6.25 | 12.5 | 25 | 12.5 | 6.25 | 12.5 | 6.25 | |
| Observed on mixed background (n = 184), % (n) | 5.43 (10) | 10.33 (19) | 5.43 (10) | 14.13 (26) | 27.17 (50) | 10.33 (19) | 5.43 (10) | 15.76 (29) | 5.98 (11) | 0.67 |
| Observed on C57BL/6J (n = 343), % (n) | 2.62 (9) | 8.16 (28) | 3.21 (11) | 16.91 (58) | 26.82 (92) | 12.83 (44) | 7.00 (24) | 16.91 (58) | 5.54 (19) | 0.028 |
| Mcfd2−/−Lman1+/gt1 × Mcfd2+/−Lman1+/gt1 | M−/−,Lgt1/gt1 | M+/−,Lgt1/gt1 | M−/−,L+/gt1 | M+/−,L+/gt1 | M−/−,L+/+ | M+/−,L+/+ | ||||
| Expected, % | 12.5 | 12.5 | 25 | 25 | 12.5 | 12.5 | ||||
| Observed on C57BL/6J (n = 342), % (n) | 5.85 (20) | 9.06 (31) | 28.65 (98) | 22.81 (78) | 14.91 (51) | 18.71 (64) | 0.004 | |||
| Crosses . | Genotype distribution . | P . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mcfd2+/−Lman1+/gt1 × Mcfd2+/−Lman1+/gt1 | M−/−,Lgt1/gt1 | M+/−,Lgt1/gt1 | M+/+,Lgt1/gt1 | M−/−,L+/gt1 | M+/−,L+/gt1 | M+/+,L+/gt1 | M−/−,L+/+ | M+/−,L+/+ | M+/+,L+/+ | |
| Expected, % | 6.25 | 12.5 | 6.25 | 12.5 | 25 | 12.5 | 6.25 | 12.5 | 6.25 | |
| Observed on mixed background (n = 184), % (n) | 5.43 (10) | 10.33 (19) | 5.43 (10) | 14.13 (26) | 27.17 (50) | 10.33 (19) | 5.43 (10) | 15.76 (29) | 5.98 (11) | 0.67 |
| Observed on C57BL/6J (n = 343), % (n) | 2.62 (9) | 8.16 (28) | 3.21 (11) | 16.91 (58) | 26.82 (92) | 12.83 (44) | 7.00 (24) | 16.91 (58) | 5.54 (19) | 0.028 |
| Mcfd2−/−Lman1+/gt1 × Mcfd2+/−Lman1+/gt1 | M−/−,Lgt1/gt1 | M+/−,Lgt1/gt1 | M−/−,L+/gt1 | M+/−,L+/gt1 | M−/−,L+/+ | M+/−,L+/+ | ||||
| Expected, % | 12.5 | 12.5 | 25 | 25 | 12.5 | 12.5 | ||||
| Observed on C57BL/6J (n = 342), % (n) | 5.85 (20) | 9.06 (31) | 28.65 (98) | 22.81 (78) | 14.91 (51) | 18.71 (64) | 0.004 | |||
P values were calculated for Mcfd2−/−Lman1gt1/gt1 mice vs all other genotypes using logistic regression.
L, Lman1; M, Mcfd2.