Patient characteristics
| Characteristics . | No. of patients (%) (n = 12) . |
|---|---|
| Sex | |
| Male | 10 (83) |
| Female | 2 (17) |
| Age, y | |
| Median | 64 |
| Range | 50-75 |
| ECOG performance status | |
| 0 | 4 (33) |
| 1 | 8 (67) |
| Rai stage | |
| I/II | 6 (50) |
| III/IV | 6 (50) |
| Interphase cytogenetic abnormality (FISH) | |
| Del 13q | 1 (8) |
| Trisomy 12 | 3 (25) |
| Del 11q | 3 (25) |
| Del 17p | 1 (8) |
| No CLL abnormalities by FISH | 4 (33) |
| Unmutated IGVH | 8 (67) |
| Karyotype (chromosomal banding analysis) | |
| Normal karyotype | 4 (40) |
| 1 abnormality | 1 (10) |
| 2 abnormalities | 2 (20) |
| Complex karyotype | 3 (30) |
| Data missing | 2 |
| CD38 expression >30% | 2 (17) |
| Zap-70 expression >20% | 6 (50) |
| Characteristics . | No. of patients (%) (n = 12) . |
|---|---|
| Sex | |
| Male | 10 (83) |
| Female | 2 (17) |
| Age, y | |
| Median | 64 |
| Range | 50-75 |
| ECOG performance status | |
| 0 | 4 (33) |
| 1 | 8 (67) |
| Rai stage | |
| I/II | 6 (50) |
| III/IV | 6 (50) |
| Interphase cytogenetic abnormality (FISH) | |
| Del 13q | 1 (8) |
| Trisomy 12 | 3 (25) |
| Del 11q | 3 (25) |
| Del 17p | 1 (8) |
| No CLL abnormalities by FISH | 4 (33) |
| Unmutated IGVH | 8 (67) |
| Karyotype (chromosomal banding analysis) | |
| Normal karyotype | 4 (40) |
| 1 abnormality | 1 (10) |
| 2 abnormalities | 2 (20) |
| Complex karyotype | 3 (30) |
| Data missing | 2 |
| CD38 expression >30% | 2 (17) |
| Zap-70 expression >20% | 6 (50) |
ECOG, Eastern Cooperative Oncology Group; IGVH, immunoglobulin variable-region heavy-chain.