Table 2. Univariate and multivariable... | American Society of Hematology

Table 2.

Univariate and multivariable analysis of mutation effect on survival in 75 patients with blast phase MPNs

Variables	Univariate analysis			Multivariable analysis
Variables	HR	95% CI	P	HR	95% CI	P
JAK2 mutated	1.1	0.7-1.8	.6
ASXL1 mutated	1.2	0.7-1.8	.5
CALR mutated	0.8	0.5-1.5	.5
TET2 mutated	1.7	0.9-3.1	.08
TP53 mutated	1.3	0.7-2.4	.5
SRSF2 mutated	0.8	0.4-1.5	.5
RUNX1 mutated	2.1	1.1-3.8	.02	2.1	1.1-3.8	.03
EZH2 mutated	1.3	0.7-2.6	.4
IDH1 mutated	0.7	0.3-1.4	.3
NRAS mutated	1.6	0.7-3.3	.2
SETBP1 mutated	1.1	0.5-2.4	.8
SH2B3 mutated	1.3	0.6-2.7	.5
MPL mutated	0.7	0.3-1.4	.3
PTPN11 mutated	3.0	1.2-7.0	.01	3.0	1.1-6.6	.03
IDH2 mutated	0.9	0.3-2.6	.9
SF3B1 mutated	0.4	0.2-1.0	.05
U2AF1 mutated	0.6	0.2-1.8	.4
SUZ12 mutated	0.8	0.2-2.6	.7
CBL mutated	2.0	0.6-6.5	.2
KRAS mutated	2.2	0.7-6.9	.2
JAK1 mutated	1.5	0.5-4.9	.5

Variables	Univariate analysis			Multivariable analysis
Variables	HR	95% CI	P	HR	95% CI	P
JAK2 mutated	1.1	0.7-1.8	.6
ASXL1 mutated	1.2	0.7-1.8	.5
CALR mutated	0.8	0.5-1.5	.5
TET2 mutated	1.7	0.9-3.1	.08
TP53 mutated	1.3	0.7-2.4	.5
SRSF2 mutated	0.8	0.4-1.5	.5
RUNX1 mutated	2.1	1.1-3.8	.02	2.1	1.1-3.8	.03
EZH2 mutated	1.3	0.7-2.6	.4
IDH1 mutated	0.7	0.3-1.4	.3
NRAS mutated	1.6	0.7-3.3	.2
SETBP1 mutated	1.1	0.5-2.4	.8
SH2B3 mutated	1.3	0.6-2.7	.5
MPL mutated	0.7	0.3-1.4	.3
PTPN11 mutated	3.0	1.2-7.0	.01	3.0	1.1-6.6	.03
IDH2 mutated	0.9	0.3-2.6	.9
SF3B1 mutated	0.4	0.2-1.0	.05
U2AF1 mutated	0.6	0.2-1.8	.4
SUZ12 mutated	0.8	0.2-2.6	.7
CBL mutated	2.0	0.6-6.5	.2
KRAS mutated	2.2	0.7-6.9	.2
JAK1 mutated	1.5	0.5-4.9	.5

Only mutations with at least 3 incident cases are included in the survival analysis. Bold indicates significant values.