Univariate and multivariable analysis investigating association of patient characteristics with VTE
| Characteristics . | VTE diagnosis, n (%) . | Unadjusted OR . | Adjusted OR . | |||
|---|---|---|---|---|---|---|
| Yes (n = 181) . | No (n = 10 273) . | Estimate (95% CI) . | P . | Estimate (95% CI) . | P . | |
| SCD type | ||||||
| HbSS | 136 (75.1) | 7 196 (70.1) | — | — | ||
| HbS-B | 14 (7.7) | 886 (8.6) | 0.86 (0.50-1.49) | .5950 | ||
| HbSC | 16 (8.8) | 1 305 (12.7) | 0.67 (0.40-1.2) | .1219 | ||
| Unspecified | 15 (8.3) | 886 (8.6) | 0.92 (0.54-1.57) | .7634 | ||
| Stroke | ||||||
| No | 137 (75.7) | 9 598 (93.4) | — | — | — | — |
| Yes | 44 (24.3) | 675 (6.6) | 4.60 (3.25-6.51) | <.0001 | 2.19 (1.45-3.21) | <.0001 |
| Congenital heart disease | ||||||
| No | 177 (97.8) | 10 194 (99.2) | — | — | ||
| Yes | 4 (2.2) | 79 (0.8) | 3.25 (1.24-8.55) | .0168 | ||
| IBD | ||||||
| No | 180 (99.5) | 10 257 (99.8) | — | — | ||
| Yes | 1 (0.5) | 16 (0.2) | 5.16 (0.92-29.03) | .0624 | ||
| Chronic renal disease | ||||||
| No | 173 (95.6) | 10 239 (99.7) | — | — | — | — |
| Yes | 8 (4.4) | 34 (0.3) | 14.54 (6.70-31.53) | <.0001 | 4.32 (1.69-11.07) | .0023 |
| Cancer | ||||||
| No | 181 (100.0) | 10 261 (99.9) | — | — | ||
| Yes | 0 (0.0) | 12 (0.1) | 2.25 (0.12-43.08) | .5893 | ||
| Obese | ||||||
| No | 161 (89.0) | 9 942 (96.8) | — | — | ||
| Yes | 20 (11.0) | 331 (3.2) | 3.81 (2.37-6.11) | <.0001 | ||
| Sex | ||||||
| Male | 75 (41.4) | 5 349 (52.1) | — | — | — | — |
| Female | 106 (58.6) | 4 924 (47.9) | 1.53 (1.14-2.06) | .0049 | 1.60 (1.17-2.20) | .0035 |
| OCP | ||||||
| No | 178 (98.3) | 10 224 (99.5) | — | — | ||
| Yes | 3 (1.7) | 49 (0.5) | 4.05 (1.34-12.22) | .0131 | ||
| Any CVL | ||||||
| No | 84 (46.4) | 8 848 (86.1) | — | — | — | — |
| Yes | 97 (53.6) | 1 425 (13.9) | 7.16 (5.32-9.64) | <.0001 | 3.47 (2.49-4.83) | <.0001 |
| ICU stay | ||||||
| No | 124 (68.5) | 9 874 (93.8) | — | — | — | — |
| Yes | 57 (31.5) | 638 (6.2) | 5.42 (4.02-7.30) | <.0001 | 3.16 (2.13-4.69) | <.0001 |
| Median age at VTE or censoring | 15.9 y | 10.6 y | 1.10 (1.07-1.13) | <.0001 | 1.08 (1.05-1.11) | <.0001 |
| Median length of hospital stay | 8 d | 3 d | 1.08 (1.07-1.10) | <.0001 | 1.05 (1.04-1.06) | <.0001 |
| Characteristics . | VTE diagnosis, n (%) . | Unadjusted OR . | Adjusted OR . | |||
|---|---|---|---|---|---|---|
| Yes (n = 181) . | No (n = 10 273) . | Estimate (95% CI) . | P . | Estimate (95% CI) . | P . | |
| SCD type | ||||||
| HbSS | 136 (75.1) | 7 196 (70.1) | — | — | ||
| HbS-B | 14 (7.7) | 886 (8.6) | 0.86 (0.50-1.49) | .5950 | ||
| HbSC | 16 (8.8) | 1 305 (12.7) | 0.67 (0.40-1.2) | .1219 | ||
| Unspecified | 15 (8.3) | 886 (8.6) | 0.92 (0.54-1.57) | .7634 | ||
| Stroke | ||||||
| No | 137 (75.7) | 9 598 (93.4) | — | — | — | — |
| Yes | 44 (24.3) | 675 (6.6) | 4.60 (3.25-6.51) | <.0001 | 2.19 (1.45-3.21) | <.0001 |
| Congenital heart disease | ||||||
| No | 177 (97.8) | 10 194 (99.2) | — | — | ||
| Yes | 4 (2.2) | 79 (0.8) | 3.25 (1.24-8.55) | .0168 | ||
| IBD | ||||||
| No | 180 (99.5) | 10 257 (99.8) | — | — | ||
| Yes | 1 (0.5) | 16 (0.2) | 5.16 (0.92-29.03) | .0624 | ||
| Chronic renal disease | ||||||
| No | 173 (95.6) | 10 239 (99.7) | — | — | — | — |
| Yes | 8 (4.4) | 34 (0.3) | 14.54 (6.70-31.53) | <.0001 | 4.32 (1.69-11.07) | .0023 |
| Cancer | ||||||
| No | 181 (100.0) | 10 261 (99.9) | — | — | ||
| Yes | 0 (0.0) | 12 (0.1) | 2.25 (0.12-43.08) | .5893 | ||
| Obese | ||||||
| No | 161 (89.0) | 9 942 (96.8) | — | — | ||
| Yes | 20 (11.0) | 331 (3.2) | 3.81 (2.37-6.11) | <.0001 | ||
| Sex | ||||||
| Male | 75 (41.4) | 5 349 (52.1) | — | — | — | — |
| Female | 106 (58.6) | 4 924 (47.9) | 1.53 (1.14-2.06) | .0049 | 1.60 (1.17-2.20) | .0035 |
| OCP | ||||||
| No | 178 (98.3) | 10 224 (99.5) | — | — | ||
| Yes | 3 (1.7) | 49 (0.5) | 4.05 (1.34-12.22) | .0131 | ||
| Any CVL | ||||||
| No | 84 (46.4) | 8 848 (86.1) | — | — | — | — |
| Yes | 97 (53.6) | 1 425 (13.9) | 7.16 (5.32-9.64) | <.0001 | 3.47 (2.49-4.83) | <.0001 |
| ICU stay | ||||||
| No | 124 (68.5) | 9 874 (93.8) | — | — | — | — |
| Yes | 57 (31.5) | 638 (6.2) | 5.42 (4.02-7.30) | <.0001 | 3.16 (2.13-4.69) | <.0001 |
| Median age at VTE or censoring | 15.9 y | 10.6 y | 1.10 (1.07-1.13) | <.0001 | 1.08 (1.05-1.11) | <.0001 |
| Median length of hospital stay | 8 d | 3 d | 1.08 (1.07-1.10) | <.0001 | 1.05 (1.04-1.06) | <.0001 |
—, Reference; IBD, inflammatory bowel disease; OCP, estrogen-containing oral contraceptive pill.