Top canonical pathways in normal LCs
| Canonical pathways . | P, -log . | z-score . | Prediction . | Ratio (%) . |
|---|---|---|---|---|
| Rho GDI signaling | 2.594 | −1.964 | Down | 28/172 (16.3) |
| FGF signaling | 3.137 | −1.886 | Down | 18/85 (21.2) |
| VEGF signaling pathway | 2.487 | −2.000 | Down | 17/89 (19.1) |
| Chemokine signaling | 3.9 | −2.668 | Down | 17/68 (25) |
| Canonical pathways . | P, -log . | z-score . | Prediction . | Ratio (%) . |
|---|---|---|---|---|
| Rho GDI signaling | 2.594 | −1.964 | Down | 28/172 (16.3) |
| FGF signaling | 3.137 | −1.886 | Down | 18/85 (21.2) |
| VEGF signaling pathway | 2.487 | −2.000 | Down | 17/89 (19.1) |
| Chemokine signaling | 3.9 | −2.668 | Down | 17/68 (25) |
IPA analysis of LC-SVEC gene signature for top-changed canonical pathways in LCs compared with SVECs. P value (displayed as the -log) indicates the significance of an association with the change of a related pathway. Positive or negative z-score predicts activation or inhibition (as indicated in the prediction column) of a pathway in LCs compared with SVECs. The ratio indicates the percentage of the genes in a given pathway in the LC-SVEC gene signature relative to the total number of genes that make up a given pathway in the whole genome.