Final estimates of parameters in the PT-response models
| Parameter* . | Description . | Estimate . | RSE, % . | 95% CI . |
|---|---|---|---|---|
| E0ISSE | Log odds of the placebo response of ischemic stroke/SE | −2.93 | 5.49 | −3.24, −2.61 |
| E0MB | Log odds of the placebo response of major bleeding | −4.17 | 1.45 | −4.29, −4.05 |
| EwISSE | Log odds ratio of dose-adjusted warfarin for ischemic stroke/SE compared with that of the placebo control | −1.49 | 10.3 | −1.79, −1.19 |
| EwMB | Log odds ratio of dose-adjusted warfarin for major bleeding compared with that of the placebo control | 0.796 | 9.22 | 0.653, 0.940 |
| θ1 | Exponent factor characterizing the slope of the double exponential model for ischemic stroke/SE | 6.96 | 15.4 | 4.87, 9.06 |
| θ2 | Exponent factor characterizing the steepness of the double exponential model for ischemic stroke/SE | −14.1 | 8.43 | −16.4, −11.8 |
| θ3 | Change in log odds of major bleeding for every 1-unit change in log PT ratio | 1.92 | 8.32 | 1.61, 2.23 |
| ω2 | Variance of the intertrial variability in the placebo response of ischemic stroke/SE | 0.00529 | 36.0 | 0.00155, 0.00902 |
| Parameter* . | Description . | Estimate . | RSE, % . | 95% CI . |
|---|---|---|---|---|
| E0ISSE | Log odds of the placebo response of ischemic stroke/SE | −2.93 | 5.49 | −3.24, −2.61 |
| E0MB | Log odds of the placebo response of major bleeding | −4.17 | 1.45 | −4.29, −4.05 |
| EwISSE | Log odds ratio of dose-adjusted warfarin for ischemic stroke/SE compared with that of the placebo control | −1.49 | 10.3 | −1.79, −1.19 |
| EwMB | Log odds ratio of dose-adjusted warfarin for major bleeding compared with that of the placebo control | 0.796 | 9.22 | 0.653, 0.940 |
| θ1 | Exponent factor characterizing the slope of the double exponential model for ischemic stroke/SE | 6.96 | 15.4 | 4.87, 9.06 |
| θ2 | Exponent factor characterizing the steepness of the double exponential model for ischemic stroke/SE | −14.1 | 8.43 | −16.4, −11.8 |
| θ3 | Change in log odds of major bleeding for every 1-unit change in log PT ratio | 1.92 | 8.32 | 1.61, 2.23 |
| ω2 | Variance of the intertrial variability in the placebo response of ischemic stroke/SE | 0.00529 | 36.0 | 0.00155, 0.00902 |
ISSE, ischemic stroke/systemic embolism; MB, major bleeding; RSE, relative standard error.
Refer to equations 1 and 2 in the text.