Table 6.

Incidence of AL amyloidosis in years 2008 to 2011

No. of cases per million person-years (numerator/denominator*)
SexAge, y2008200920102011
Female 18-34 0.4 (1/2 328 356) 0.0 (0/3 334 994) 1.6 (5/3 179 448) 0.9 (3/3 452 830) 
35-54 5.4 (24/4 458 641) 6.6 (40/6 073 904) 6.3 (37/5 867 133) 4.6 (28/6 095 899) 
55-64 20.8 (42/2 022 079) 11.2 (31/2 756 439) 13.5 (37/2 745 827) 19.3 (57/2 958 448) 
65+ 26.7 (28/1 050 168) 33.0 (51/1 543 818) 20.5 (31/1 514 234) 34.6 (62/1 792 636) 
All female 9.6 (95/9 859 244) 8.9 (122/13 709 155) 8.3 (110/13 306 642) 10.5 (150/14 299 813) 
Male 18-34 0.9 (2/2 140 796) 0.3 (1/3 048 029) 0.3 (1/2 895 210) 0.0 (0/3 172 642) 
35-54 5.1 (20/3 953 483) 4.8 (26/5 404 324) 4.0 (21/5 244 983) 2.9 (16/5 449 578) 
55-64 25.5 (46/1 801 702) 14.5 (36/2 480 625) 16.6 (41/2 473 344) 19.0 (50/2 625 058) 
65+ 58.8 (50/849 850) 54.5 (67/1 230 196) 57.1 (72/1 261 151) 55.3 (79/1 429 149) 
All male 13.5 (118/8 745 831) 10.7 (130/12 163 174) 11.4 (135/11 874 688) 11.4 (145/12 676 427) 
All sex 18-34 0.7 (3/4 469 152) 0.2 (1/6 383 023) 1.0 (6/6 074 658) 0.5 (3/6 625 472) 
35-54 5.2 (44/8 412 124) 5.8 (66/11 478 228) 5.2 (58/11 112 116) 3.8 (44/11 545 477) 
55-64 23.0 (88/3 823 781) 12.8 (67/5 237 064) 14.9 (78/5 219 171) 19.2 (107/5 583 506) 
65+ 41.1 (78/1 900 018) 42.5 (118/2 774 014) 37.1 (103/2 775 385) 43.8 (141/3 221 785) 
All patients 11.4 (213/18 605 075) 9.7 (252/25 872 329) 9.7 (245/25 181 330) 10.9 (295/26 976 240) 
US adult population Age-sex adjustedrate, no. of cases per million person-years 
 Female 10.4 10.4 8.7 11.5 
 Male 15.2 12.5 12.9 12.5 
 All 12.7 11.4 10.8 12.0 
No. of cases per million person-years (numerator/denominator*)
SexAge, y2008200920102011
Female 18-34 0.4 (1/2 328 356) 0.0 (0/3 334 994) 1.6 (5/3 179 448) 0.9 (3/3 452 830) 
35-54 5.4 (24/4 458 641) 6.6 (40/6 073 904) 6.3 (37/5 867 133) 4.6 (28/6 095 899) 
55-64 20.8 (42/2 022 079) 11.2 (31/2 756 439) 13.5 (37/2 745 827) 19.3 (57/2 958 448) 
65+ 26.7 (28/1 050 168) 33.0 (51/1 543 818) 20.5 (31/1 514 234) 34.6 (62/1 792 636) 
All female 9.6 (95/9 859 244) 8.9 (122/13 709 155) 8.3 (110/13 306 642) 10.5 (150/14 299 813) 
Male 18-34 0.9 (2/2 140 796) 0.3 (1/3 048 029) 0.3 (1/2 895 210) 0.0 (0/3 172 642) 
35-54 5.1 (20/3 953 483) 4.8 (26/5 404 324) 4.0 (21/5 244 983) 2.9 (16/5 449 578) 
55-64 25.5 (46/1 801 702) 14.5 (36/2 480 625) 16.6 (41/2 473 344) 19.0 (50/2 625 058) 
65+ 58.8 (50/849 850) 54.5 (67/1 230 196) 57.1 (72/1 261 151) 55.3 (79/1 429 149) 
All male 13.5 (118/8 745 831) 10.7 (130/12 163 174) 11.4 (135/11 874 688) 11.4 (145/12 676 427) 
All sex 18-34 0.7 (3/4 469 152) 0.2 (1/6 383 023) 1.0 (6/6 074 658) 0.5 (3/6 625 472) 
35-54 5.2 (44/8 412 124) 5.8 (66/11 478 228) 5.2 (58/11 112 116) 3.8 (44/11 545 477) 
55-64 23.0 (88/3 823 781) 12.8 (67/5 237 064) 14.9 (78/5 219 171) 19.2 (107/5 583 506) 
65+ 41.1 (78/1 900 018) 42.5 (118/2 774 014) 37.1 (103/2 775 385) 43.8 (141/3 221 785) 
All patients 11.4 (213/18 605 075) 9.7 (252/25 872 329) 9.7 (245/25 181 330) 10.9 (295/26 976 240) 
US adult population Age-sex adjustedrate, no. of cases per million person-years 
 Female 10.4 10.4 8.7 11.5 
 Male 15.2 12.5 12.9 12.5 
 All 12.7 11.4 10.8 12.0 
*

Number of members enrolled with a health plan from July 1st of previous year to June 30th of the calendar year.

Based on US 2010 census data. Overall rates were adjusted by age and sex distribution, and rates by sex were adjusted by age distribution within specific sex.

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