Prevalence of AL amyloidosis in years 2012 to 2015
| . | . | No. of cases per million (numerator/denominator*) . | APC† . | ||||
|---|---|---|---|---|---|---|---|
| Sex . | Age, y . | 2012 . | 2013 . | 2014 . | 2015 . | APC %† (95% CI) . | P‡ . |
| Female | 18-34 | 1.3 (8/6 027 440) | 1.2 (6/4 905 115) | 1.9 (10/5 174 857) | 2.5 (8/3 203 983) | 11.6 (−4.2 to 30.1) | .133 |
| 35-54 | 10.6 (91/8 598 579) | 13.0 (90/6 901 069) | 14.7 (104/7 087 336) | 21.1 (91/4 306 274) | 11.3 (5.8-17.2) | .002 | |
| 55-64 | 45.4 (183/4 034 960) | 50.7 (169/3 334 349) | 53.6 (187/3 487 785) | 65.4 (144/2 200 422) | 10.1 (8.1-12.2) | <.001 | |
| 65+ | 79.9 (185/2 313 999) | 98.0 (201/2 050 617) | 92.6 (167/1 803 890) | 134.3 (146/1 086 773) | 12.4 (8.4-16.6) | <.001 | |
| All female | 22.3 (467/20 974 978) | 27.1 (466/17 191 150) | 26.7 (468/17 553 868) | 36.0 (389/10 797 452) | 11.6 (9.5-13.8) | <.001 | |
| Male | 18-34 | 1.2 (7/5 750 069) | 0.4 (2/4 609 448) | 0.6 (3/4 942 947) | 1.3 (4/3 008 324) | 6.0 (−11.5 to 26.9) | .462 |
| 35-54 | 13.4 (104/7 785 622) | 17.0 (104/6 132 334) | 16.6 (106/6 375 666) | 18.5 (70/3 785 395) | 11.6 (9.1-14.1) | <.001 | |
| 55-64 | 57.0 (204/3 580 220) | 61.0 (177/2 903 982) | 66.7 (205/3 073 703) | 80.3 (152/1 893 874) | 10.5 (8.5-12.5) | <.001 | |
| 65+ | 159.4 (298/1 869 245) | 185.1 (314/1 696 636) | 184.8 (279/1 509 767) | 239.6 (210/876 397) | 13.2 (9.7-16.8) | <.001 | |
| All male | 32.3 (613/18 985 156) | 38.9 (597/15 342 400) | 37.3 (593/15 902 083) | 45.6 (436/9 563 990) | 12.3 (10.6-13.9) | <.001 | |
| All sex | 18-34 | 1.3 (15/11 777 509) | 0.8 (8/9 514 563) | 1.3 (13/10 117 804) | 1.9 (12/6 212 307) | 11.9 (−0.9 to 26.3) | .064 |
| 35-54 | 11.9 (195/16 384 201) | 14.9 (194/13 033 403) | 15.6 (210/13 463 002) | 19.9 (161/8 091 669) | 11.5 (7.9-15.2) | <.001 | |
| 55-64 | 50.8 (387/7 615 180) | 55.5 (346/6 238 331) | 59.7 (392/6 561 488) | 72.3 (296/4 094 296) | 10.2 (8.4-12.1) | <.001 | |
| 65+ | 115.5 (483/4 183 244) | 137.4 (515/3 747 253) | 134.6 (446/3 313 657) | 181.3 (356/1 963 170) | 12.9 (9.4-16.6) | <.001 | |
| All patients | 27.0 (1080/39 960 134) | 32.7 (1063/32 533 550) | 31.7 (1061/33 455 951) | 40.5 (825/20 361 442) | 12.0 (10.3-13.7) | <.001 | |
| US adult population | Age-sex adjusted§rate, no. of cases per million | ||||||
| Female | 26.5 | 31.7 | 31.9 | 44.2 | 11.5 (9.2-13.9) | <.001 | |
| Male | 38.6 | 44.3 | 45.0 | 56.5 | 12.3 (10.6-14.0) | <.001 | |
| All | 32.4 | 37.8 | 38.3 | 50.1 | 11.9 (10.1-13.8) | <.001 | |
| . | . | No. of cases per million (numerator/denominator*) . | APC† . | ||||
|---|---|---|---|---|---|---|---|
| Sex . | Age, y . | 2012 . | 2013 . | 2014 . | 2015 . | APC %† (95% CI) . | P‡ . |
| Female | 18-34 | 1.3 (8/6 027 440) | 1.2 (6/4 905 115) | 1.9 (10/5 174 857) | 2.5 (8/3 203 983) | 11.6 (−4.2 to 30.1) | .133 |
| 35-54 | 10.6 (91/8 598 579) | 13.0 (90/6 901 069) | 14.7 (104/7 087 336) | 21.1 (91/4 306 274) | 11.3 (5.8-17.2) | .002 | |
| 55-64 | 45.4 (183/4 034 960) | 50.7 (169/3 334 349) | 53.6 (187/3 487 785) | 65.4 (144/2 200 422) | 10.1 (8.1-12.2) | <.001 | |
| 65+ | 79.9 (185/2 313 999) | 98.0 (201/2 050 617) | 92.6 (167/1 803 890) | 134.3 (146/1 086 773) | 12.4 (8.4-16.6) | <.001 | |
| All female | 22.3 (467/20 974 978) | 27.1 (466/17 191 150) | 26.7 (468/17 553 868) | 36.0 (389/10 797 452) | 11.6 (9.5-13.8) | <.001 | |
| Male | 18-34 | 1.2 (7/5 750 069) | 0.4 (2/4 609 448) | 0.6 (3/4 942 947) | 1.3 (4/3 008 324) | 6.0 (−11.5 to 26.9) | .462 |
| 35-54 | 13.4 (104/7 785 622) | 17.0 (104/6 132 334) | 16.6 (106/6 375 666) | 18.5 (70/3 785 395) | 11.6 (9.1-14.1) | <.001 | |
| 55-64 | 57.0 (204/3 580 220) | 61.0 (177/2 903 982) | 66.7 (205/3 073 703) | 80.3 (152/1 893 874) | 10.5 (8.5-12.5) | <.001 | |
| 65+ | 159.4 (298/1 869 245) | 185.1 (314/1 696 636) | 184.8 (279/1 509 767) | 239.6 (210/876 397) | 13.2 (9.7-16.8) | <.001 | |
| All male | 32.3 (613/18 985 156) | 38.9 (597/15 342 400) | 37.3 (593/15 902 083) | 45.6 (436/9 563 990) | 12.3 (10.6-13.9) | <.001 | |
| All sex | 18-34 | 1.3 (15/11 777 509) | 0.8 (8/9 514 563) | 1.3 (13/10 117 804) | 1.9 (12/6 212 307) | 11.9 (−0.9 to 26.3) | .064 |
| 35-54 | 11.9 (195/16 384 201) | 14.9 (194/13 033 403) | 15.6 (210/13 463 002) | 19.9 (161/8 091 669) | 11.5 (7.9-15.2) | <.001 | |
| 55-64 | 50.8 (387/7 615 180) | 55.5 (346/6 238 331) | 59.7 (392/6 561 488) | 72.3 (296/4 094 296) | 10.2 (8.4-12.1) | <.001 | |
| 65+ | 115.5 (483/4 183 244) | 137.4 (515/3 747 253) | 134.6 (446/3 313 657) | 181.3 (356/1 963 170) | 12.9 (9.4-16.6) | <.001 | |
| All patients | 27.0 (1080/39 960 134) | 32.7 (1063/32 533 550) | 31.7 (1061/33 455 951) | 40.5 (825/20 361 442) | 12.0 (10.3-13.7) | <.001 | |
| US adult population | Age-sex adjusted§rate, no. of cases per million | ||||||
| Female | 26.5 | 31.7 | 31.9 | 44.2 | 11.5 (9.2-13.9) | <.001 | |
| Male | 38.6 | 44.3 | 45.0 | 56.5 | 12.3 (10.6-14.0) | <.001 | |
| All | 32.4 | 37.8 | 38.3 | 50.1 | 11.9 (10.1-13.8) | <.001 | |
Number of members enrolled with a health plan on June 30th of each calendar year.
APC (for Tables 4 and 5).
P values are for the trend of APC, reflecting whether the APC is different from zero (for Tables 4 and 5).
Based on US 2010 census data. Overall rates were adjusted by age and sex distribution, and rates by sex were adjusted by age distribution within specific sex.