Thrombin generation is similar in F13a+/+, F13a+/−, and F13a−/− mice
| . | PPP . | PRP . | ||||
|---|---|---|---|---|---|---|
| F13a+/+ . | F13a+/− . | F13a−/− . | F13a+/+ . | F13a+/− . | F13a−/− . | |
| Lag time, min | 1.6 ± 0.2 | 1.7 ± 0.1 | 1.6 ± 0.1 | 2.3 ± 0.2 | 2.3 ± 0.1 | 2.33 ± 0.2 |
| Time to peak, min | 3.6 ± 0.5 | 3.7 ± 0.1 | 3.5 ± 0.1 | 5.6 ± 0.3 | 6.0 ± 0.4 | 4.9 ± 0.2 |
| Velocity, nM/min | 35.8 ± 2.6 | 33.8 ± 1.2 | 34.1 ± 2.6 | 18.0 ± 2.7 | 13.8 ± 3.3 | 22.3 ± 5.3 |
| Peak thrombin, nM | 70.1 ± 2.9 | 66.7 ± 1.5 | 65.3 ± 3.9 | 55.2 ± 6.0 | 46.4 ± 6.6 | 52.7 ± 3.7 |
| Endogenous thrombin potential, nM*min | 387.7 ± 34.4 | 417.5 ± 68.7 | 284.6 ± 18.5 | 804.8 ± 164.6 | 621.0 ± 63.1 | 611.4 ± 50.0 |
| . | PPP . | PRP . | ||||
|---|---|---|---|---|---|---|
| F13a+/+ . | F13a+/− . | F13a−/− . | F13a+/+ . | F13a+/− . | F13a−/− . | |
| Lag time, min | 1.6 ± 0.2 | 1.7 ± 0.1 | 1.6 ± 0.1 | 2.3 ± 0.2 | 2.3 ± 0.1 | 2.33 ± 0.2 |
| Time to peak, min | 3.6 ± 0.5 | 3.7 ± 0.1 | 3.5 ± 0.1 | 5.6 ± 0.3 | 6.0 ± 0.4 | 4.9 ± 0.2 |
| Velocity, nM/min | 35.8 ± 2.6 | 33.8 ± 1.2 | 34.1 ± 2.6 | 18.0 ± 2.7 | 13.8 ± 3.3 | 22.3 ± 5.3 |
| Peak thrombin, nM | 70.1 ± 2.9 | 66.7 ± 1.5 | 65.3 ± 3.9 | 55.2 ± 6.0 | 46.4 ± 6.6 | 52.7 ± 3.7 |
| Endogenous thrombin potential, nM*min | 387.7 ± 34.4 | 417.5 ± 68.7 | 284.6 ± 18.5 | 804.8 ± 164.6 | 621.0 ± 63.1 | 611.4 ± 50.0 |
Thrombin generation was measured by calibrated automated thrombography. Data show mean ± SEM and were analyzed by ANOVA with Dunnett’s post-hoc test (n = 4-6).