Risk of fractures in MGUS and light-chain MGUS
| Fractures . | No. of fractures . | HR* . | 95% CI . | ||
|---|---|---|---|---|---|
| Lower . | Upper . | ||||
| All fractures | |||||
| All | No MGUS | 1198 | — | ||
| MGUS | 74 | 1.22 | 0.96 | 1.54 | |
| LC-MGUS | 62 | 1.06 | 0.82 | 1.36 | |
| Men | No MGUS | 318 | — | ||
| MGUS | 34 | 1.46 (P = .038) | 1.02 | 2.07 | |
| LC-MGUS | 19 | 0.74 | 0.47 | 1.18 | |
| Women | No MGUS | 880 | — | ||
| MGUS | 40 | 1.02 | 0.74 | 1.40 | |
| LC-MGUS | 43 | 1.29 | 0.95 | 1.75 | |
| Axial fractures | |||||
| All | No MGUS | 443 | — | ||
| MGUS | 31 | 1.33 | 0.92 | 1.91 | |
| LC-MGUS | 32 | 1.41 | 0.98 | 2.02 | |
| Men | No MGUS | 131 | — | ||
| MGUS | 15 | 1.54 | 0.90 | 2.64 | |
| LC-MGUS | 9 | 0.88 | 0.44 | 1.73 | |
| Women | No MGUS | 312 | — | ||
| MGUS | 16 | 1.18 | 0.71 | 1.95 | |
| LC-MGUS | 23 | 1.86 (P = .004) | 1.21 | 2.84 | |
| Peripheral fractures | |||||
| All | No MGUS | 950 | — | ||
| MGUS | 58 | 1.23 | 0.94 | 1.61 | |
| LC-MGUS | 44 | 0.95 | 0.70 | 1.29 | |
| Men | No MGUS | 222 | — | ||
| MGUS | 23 | 1.39 | 0.91 | 2.14 | |
| LC-MGUS | 13 | 0.71 | 0.41 | 1.25 | |
| Women | No MGUS | 728 | — | ||
| MGUS | 35 | 1.28 | 0.91 | 1.80 | |
| LC-MGUS | 31 | 1.55 (P = .02) | 1.07 | 2.22 | |
| Fractures . | No. of fractures . | HR* . | 95% CI . | ||
|---|---|---|---|---|---|
| Lower . | Upper . | ||||
| All fractures | |||||
| All | No MGUS | 1198 | — | ||
| MGUS | 74 | 1.22 | 0.96 | 1.54 | |
| LC-MGUS | 62 | 1.06 | 0.82 | 1.36 | |
| Men | No MGUS | 318 | — | ||
| MGUS | 34 | 1.46 (P = .038) | 1.02 | 2.07 | |
| LC-MGUS | 19 | 0.74 | 0.47 | 1.18 | |
| Women | No MGUS | 880 | — | ||
| MGUS | 40 | 1.02 | 0.74 | 1.40 | |
| LC-MGUS | 43 | 1.29 | 0.95 | 1.75 | |
| Axial fractures | |||||
| All | No MGUS | 443 | — | ||
| MGUS | 31 | 1.33 | 0.92 | 1.91 | |
| LC-MGUS | 32 | 1.41 | 0.98 | 2.02 | |
| Men | No MGUS | 131 | — | ||
| MGUS | 15 | 1.54 | 0.90 | 2.64 | |
| LC-MGUS | 9 | 0.88 | 0.44 | 1.73 | |
| Women | No MGUS | 312 | — | ||
| MGUS | 16 | 1.18 | 0.71 | 1.95 | |
| LC-MGUS | 23 | 1.86 (P = .004) | 1.21 | 2.84 | |
| Peripheral fractures | |||||
| All | No MGUS | 950 | — | ||
| MGUS | 58 | 1.23 | 0.94 | 1.61 | |
| LC-MGUS | 44 | 0.95 | 0.70 | 1.29 | |
| Men | No MGUS | 222 | — | ||
| MGUS | 23 | 1.39 | 0.91 | 2.14 | |
| LC-MGUS | 13 | 0.71 | 0.41 | 1.25 | |
| Women | No MGUS | 728 | — | ||
| MGUS | 35 | 1.28 | 0.91 | 1.80 | |
| LC-MGUS | 31 | 1.55 (P = .02) | 1.07 | 2.22 | |
— represents the reference group. Bold values represent P < .05.
Adjusted for age and sex.