Table 2. Associations between... | American Society of Hematology

Table 2.

Associations between circulating fibrocytes and pulmonary function in adults with SCD

		χ² test P value and sensitivity, specificity
Fibrocyte	Threshold	Abnormal FEV₁			Abnormal FVC			Abnormal TLC
Fibrocyte	Threshold	P			P			P
CD45⁺Col1⁺	1 500 000	.009	TPR	0.63	.006	TPR	0.69	.150	TPR	0.53
			95% CI	(0.38-0.84)		95% CI	(0.41-0.89)		95% CI	(0.29-0.77)
			SPC	0.72		SPC	0.72		SPC	0.67
			95% CI	(0.58-0.84)		95% CI	(0.58-0.83)		95% CI	(0.55-0.80)
CD45⁺Col1⁺CXCR4⁺	1 100 000	.007	TPR	0.63	.003	TPR	0.69	.360	TPR	0.47
			95% CI	(0.38-0.84)		95% CI	(0.41-0.89)		95% CI	(0.23-0.71)
			SPC	0.72		SPC	0.72		SPC	0.65
			95% CI	(0.56-0.84)		95% CI	(0.58-0.83)		95% CI	(0.52-0.78)
CD45⁺Col1⁺α−SMA⁺	420 000	.010	TPR	0.90	.036	TPR	0.88	.020	TPR	0.88
			95% CI	(0.67-0.99)		95% CI	(0.62-0.99)		95% CI	(0.72-0.99)
			SPC	0.46		SPC	0.43		SPC	0.44
			95% CI	(0.32-0 .61)		95% CI	(0.30-0.58)		95% CI	(0.31-0.58)

		χ² test P value and sensitivity, specificity
Fibrocyte	Threshold	Abnormal FEV₁			Abnormal FVC			Abnormal TLC
Fibrocyte	Threshold	P			P			P
CD45⁺Col1⁺	1 500 000	.009	TPR	0.63	.006	TPR	0.69	.150	TPR	0.53
			95% CI	(0.38-0.84)		95% CI	(0.41-0.89)		95% CI	(0.29-0.77)
			SPC	0.72		SPC	0.72		SPC	0.67
			95% CI	(0.58-0.84)		95% CI	(0.58-0.83)		95% CI	(0.55-0.80)
CD45⁺Col1⁺CXCR4⁺	1 100 000	.007	TPR	0.63	.003	TPR	0.69	.360	TPR	0.47
			95% CI	(0.38-0.84)		95% CI	(0.41-0.89)		95% CI	(0.23-0.71)
			SPC	0.72		SPC	0.72		SPC	0.65
			95% CI	(0.56-0.84)		95% CI	(0.58-0.83)		95% CI	(0.52-0.78)
CD45⁺Col1⁺α−SMA⁺	420 000	.010	TPR	0.90	.036	TPR	0.88	.020	TPR	0.88
			95% CI	(0.67-0.99)		95% CI	(0.62-0.99)		95% CI	(0.72-0.99)
			SPC	0.46		SPC	0.43		SPC	0.44
			95% CI	(0.32-0 .61)		95% CI	(0.30-0.58)		95% CI	(0.31-0.58)

Bold indicates significance (P < .05).

CI, confidence interval; SPC, specificity (true-negative rate); TPR, sensitivity (true-positive rate).