Characteristics of the study participants
| Characteristics . | Without MGUS, . | MGUS, . | LC-MGUS, . | MM, . | MM and other LP diseases, . |
|---|---|---|---|---|---|
| n = 5150 (93.9%) . | n = 300 (5.2%) . | n = 275 (4.8%) . | n = 18 (3.1%)* . | n = 29 (5.1%)* . | |
| Sex, n (%) | |||||
| Female | 3046 (59.1) | 141 (47.0) | 119 (43.3) | 10 (55.6) | 14 (48.3) |
| Male | 2104 (40.9) | 159 (53.0) | 156 (56.7) | 8 (44.4) | 15 (51.7) |
| Mean age (range), y | 76.8 (66-98) | 78.3 (67-93) | 79.4 (66-97) | 77.8 (69-87) | 77.4 (68-87) |
| BMI, mean (SD), kg/m2 | 27.0 (4.5) | 26.7 (4.1) | 27.0 (4.5) | 27.1 (2.4) | 26.5 (2.8) |
| BMI, % (n) | |||||
| <25.0 | 1716 (34.0) | 101 (34.1) | 93 (34.2) | 5 (27.8) | 8 (27.6) |
| 25.0-29.9 | 2222 (43.6) | 146 (49.3) | 121 (44.4) | 10 (55.6) | 18 (62.1) |
| ≥30.0 | 1154 (22.7) | 49 (16.6) | 58 (21.3) | 3 (16.7) | 3 (10.3) |
| BMI midlife, mean (SD), kg/m2 | 25.2 (3.6) | 25.5 (3.7) | 25.6 (3.8) | 26.2 (2.7) | 26.2 (3.2) |
| BMI midlife, n (%) | |||||
| <25 | 2686 (52.4) | 139 (46.7) | 128 (46.7) | 5 (27.8) | 8 (27.6) |
| ≥25 | 2442 (47.6) | 159 (53.3) | 146 (53.3) | 13 (72.2) | 21 (72.4) |
| Weight, mean (SD), kg | 75.3 (1.7) | 75.4 (14.2) | 76.4 (15.6) | 77.2 (13.5) | 76.8 (13.7) |
| Max weight, mean (SD), kg | 80.7 (15.5) | 82.4 (15.2) | 83.1 (16.1) | 85.4 (13.7) | 85.7 (13.8) |
| Percent body fat (BIA), mean (SD), % | 29.0 (7.9) | 26.8 (8.4) | 26.9 (7.7) | 28.7 (7.6) | 26.8 (7.9) |
| Fat (BIA), mean (SD), kg | 22.0 (7.9) | 20.5 (7.9) | 20.7 (7.4) | 22.7 (6.7) | 20.6 (7.1) |
| Total body fat (CT), mean (SD), cm2 | 494.3 (167.0) | 482.5 (166.5) | 495.6 (173.7) | 509.0 (130.0) | 478.5 (151.5) |
| Visceral fat (CT), mean (SD), cm2 | 171.9 (79.5) | 174.8 (85.1) | 187.5 (86.9) | 178.6 (91.4) | 174.1 (92.4) |
| Subcutaneous fat (CT), mean (SD), cm2 | 257.3 (112.1) | 241.0 (108.4) | 238.6 (108.4) | 261.1 (99.8) | 237.1 (100.5) |
| Waist circumference (CT), mean (SD), cm | 125.8 (14.0) | 125.7 (13.4) | 126.5 (14.2) | 127.8 (11.8) | 125.4 (13.3) |
| Waist circumference, mean (SD), cm | 100.8 (12.1) | 100.8 (11.2) | 101.6 (11.5) | 103.8 (9.2) | 101.5 (9.9) |
| Characteristics . | Without MGUS, . | MGUS, . | LC-MGUS, . | MM, . | MM and other LP diseases, . |
|---|---|---|---|---|---|
| n = 5150 (93.9%) . | n = 300 (5.2%) . | n = 275 (4.8%) . | n = 18 (3.1%)* . | n = 29 (5.1%)* . | |
| Sex, n (%) | |||||
| Female | 3046 (59.1) | 141 (47.0) | 119 (43.3) | 10 (55.6) | 14 (48.3) |
| Male | 2104 (40.9) | 159 (53.0) | 156 (56.7) | 8 (44.4) | 15 (51.7) |
| Mean age (range), y | 76.8 (66-98) | 78.3 (67-93) | 79.4 (66-97) | 77.8 (69-87) | 77.4 (68-87) |
| BMI, mean (SD), kg/m2 | 27.0 (4.5) | 26.7 (4.1) | 27.0 (4.5) | 27.1 (2.4) | 26.5 (2.8) |
| BMI, % (n) | |||||
| <25.0 | 1716 (34.0) | 101 (34.1) | 93 (34.2) | 5 (27.8) | 8 (27.6) |
| 25.0-29.9 | 2222 (43.6) | 146 (49.3) | 121 (44.4) | 10 (55.6) | 18 (62.1) |
| ≥30.0 | 1154 (22.7) | 49 (16.6) | 58 (21.3) | 3 (16.7) | 3 (10.3) |
| BMI midlife, mean (SD), kg/m2 | 25.2 (3.6) | 25.5 (3.7) | 25.6 (3.8) | 26.2 (2.7) | 26.2 (3.2) |
| BMI midlife, n (%) | |||||
| <25 | 2686 (52.4) | 139 (46.7) | 128 (46.7) | 5 (27.8) | 8 (27.6) |
| ≥25 | 2442 (47.6) | 159 (53.3) | 146 (53.3) | 13 (72.2) | 21 (72.4) |
| Weight, mean (SD), kg | 75.3 (1.7) | 75.4 (14.2) | 76.4 (15.6) | 77.2 (13.5) | 76.8 (13.7) |
| Max weight, mean (SD), kg | 80.7 (15.5) | 82.4 (15.2) | 83.1 (16.1) | 85.4 (13.7) | 85.7 (13.8) |
| Percent body fat (BIA), mean (SD), % | 29.0 (7.9) | 26.8 (8.4) | 26.9 (7.7) | 28.7 (7.6) | 26.8 (7.9) |
| Fat (BIA), mean (SD), kg | 22.0 (7.9) | 20.5 (7.9) | 20.7 (7.4) | 22.7 (6.7) | 20.6 (7.1) |
| Total body fat (CT), mean (SD), cm2 | 494.3 (167.0) | 482.5 (166.5) | 495.6 (173.7) | 509.0 (130.0) | 478.5 (151.5) |
| Visceral fat (CT), mean (SD), cm2 | 171.9 (79.5) | 174.8 (85.1) | 187.5 (86.9) | 178.6 (91.4) | 174.1 (92.4) |
| Subcutaneous fat (CT), mean (SD), cm2 | 257.3 (112.1) | 241.0 (108.4) | 238.6 (108.4) | 261.1 (99.8) | 237.1 (100.5) |
| Waist circumference (CT), mean (SD), cm | 125.8 (14.0) | 125.7 (13.4) | 126.5 (14.2) | 127.8 (11.8) | 125.4 (13.3) |
| Waist circumference, mean (SD), cm | 100.8 (12.1) | 100.8 (11.2) | 101.6 (11.5) | 103.8 (9.2) | 101.5 (9.9) |
Missing values are 65 for BMI, 25 for midlife BMI, 57 for weight, 479 for maximum weight, 1666 for percent body fat and fat, 449 for the CT variables (total body fat, visceral fat, subcutaneous fat, and CT waist circumference), and 53 for waist circumference.
BIA, bioelectrical impedance analysis; SD, standard deviation.
Proportion of cases that progressed from MGUS or LC-MGUS.