Cumulative incidence of specific causes of death among all MDS patients according to MDS risk groups
| COD . | Overall, % (95% CI) . | Low risk, % (95% CI) . | Intermediate risk, % (95% CI) . | High risk, % (95% CI) . | ||||
|---|---|---|---|---|---|---|---|---|
| 12-mo . | 24-mo . | 12-mo . | 24-mo . | 12-mo . | 24-mo . | 12-mo . | 24-mo . | |
| MDS/leukemia | 15.5 (15.1-15.9) | 23.1 (22.7-23.6) | 6.0 (5.4-6.6) | 9.9 (9.1-10.6) | 14.8 (14.3-15.3) | 22.1 (21.5-22.7) | 34.7 (33.2-36.2) | 50.4 (48.8-52.0) |
| Other leukemia or lymphoma | 1.6 (1.5-1.8) | 2.4 (2.3-2.6) | 0.6 (0.5-0.9) | 1.2 (0.9-1.5) | 1.5 (1.3-1.6) | 2.2 (2.0-2.4) | 4.0 (3.4-4.7) | 6.0 (5.3-6.8) |
| Other cancer | 0.9 (0.8-1.0) | 1.6 (1.4-1.7) | 0.9 (0.7-1.2) | 1.7 (1.4-1.8) | 0.9 (0.8-1.1) | 1.6 (1.4-1.8) | 0.8 (0.6-1.2) | 1.3 (0.1-1.7) |
| Infection | 1.7 (1.6-1.9) | 2.3 (2.1-2.5) | 1.7 (1.4-2.0) | 2.6 (2.2-3.0) | 1.7 (1.5-1.9) | 2.3 (2.1-2.5) | 1.6 (1.2-2.1) | 1.9 (1.5-2.4) |
| CVD | 5.1 (4.8-5.3) | 7.7 (7.4-8.0) | 4.3 (3.8-4.8) | 7.2 (6.6-7.9) | 5.5 (5.2-5.8) | 8.2 (7.9-8.6) | 4.3 (3.7-5.0) | 5.7 (5.0-6.5) |
| Dementia | 0.2 (0.2-0.3) | 0.3 (0.3-0.4) | 0.1 (0.04-0.2) | 0.2 (0.1-0.3) | 0.3 (0.2-0.3) | 0.4 (0.3-0.5) | 0.1 (0.05-0.3) | 0.2 (0.07-0.3) |
| COPD | 1.0 (0.9-1.1) | 1.4 (1.3-1.6) | 0.9 (0.7-1.1) | 1.5 (1.2-1.8) | 1.0 (0.9-1.2) | 1.5 (1.3-1.7) | 0.8 (0.6-1.2) | 1.0 (0.7-1.3) |
| Cirrhosis | 0.2 (0.2-0.3) | 0.4 (0.3-0.5) | 0.3 (0.2-0.4) | 0.5 (0.4-0.7) | 0.2 (0. 2-0.3) | 0.4 (0.3-0.5) | 0.1 (0.02-0.2) | 0.2 (0.08-0.4) |
| Renal | 0.4 (0.4-0.5) | 0.7 (0.6-0.8) | 0.5 (0.3-0.7) | 0.8 (0.6-1.0) | 0.5 (0.4-0.5) | 0.7 (0.6-0.8) | 0.3 (0.2-0.6) | 0.5 (0.3-0.7) |
| Accidents | 0.4 (0.3-0.5) | 0.6 (0.5-0.7) | 0.3 (0.2-0.5) | 0.5 (0.3-0.7) | 0.4 (0.3-0.5) | 0.6 (0.5-0.7) | 0.6 (0.4-0.9) | 0.8 (0.6-1.1) |
| Other | 3.4 (3.2-3.6) | 4.9 (4.6-5.1) | 3.0 (2.6-4.5) | 4.6 (4.1-5.1) | 3.5 (3.2-3.7) | 5.1 (4.8-5.4) | 3.6 (3.0-4.2) | 4.4 (3.8-5.1) |
| COD . | Overall, % (95% CI) . | Low risk, % (95% CI) . | Intermediate risk, % (95% CI) . | High risk, % (95% CI) . | ||||
|---|---|---|---|---|---|---|---|---|
| 12-mo . | 24-mo . | 12-mo . | 24-mo . | 12-mo . | 24-mo . | 12-mo . | 24-mo . | |
| MDS/leukemia | 15.5 (15.1-15.9) | 23.1 (22.7-23.6) | 6.0 (5.4-6.6) | 9.9 (9.1-10.6) | 14.8 (14.3-15.3) | 22.1 (21.5-22.7) | 34.7 (33.2-36.2) | 50.4 (48.8-52.0) |
| Other leukemia or lymphoma | 1.6 (1.5-1.8) | 2.4 (2.3-2.6) | 0.6 (0.5-0.9) | 1.2 (0.9-1.5) | 1.5 (1.3-1.6) | 2.2 (2.0-2.4) | 4.0 (3.4-4.7) | 6.0 (5.3-6.8) |
| Other cancer | 0.9 (0.8-1.0) | 1.6 (1.4-1.7) | 0.9 (0.7-1.2) | 1.7 (1.4-1.8) | 0.9 (0.8-1.1) | 1.6 (1.4-1.8) | 0.8 (0.6-1.2) | 1.3 (0.1-1.7) |
| Infection | 1.7 (1.6-1.9) | 2.3 (2.1-2.5) | 1.7 (1.4-2.0) | 2.6 (2.2-3.0) | 1.7 (1.5-1.9) | 2.3 (2.1-2.5) | 1.6 (1.2-2.1) | 1.9 (1.5-2.4) |
| CVD | 5.1 (4.8-5.3) | 7.7 (7.4-8.0) | 4.3 (3.8-4.8) | 7.2 (6.6-7.9) | 5.5 (5.2-5.8) | 8.2 (7.9-8.6) | 4.3 (3.7-5.0) | 5.7 (5.0-6.5) |
| Dementia | 0.2 (0.2-0.3) | 0.3 (0.3-0.4) | 0.1 (0.04-0.2) | 0.2 (0.1-0.3) | 0.3 (0.2-0.3) | 0.4 (0.3-0.5) | 0.1 (0.05-0.3) | 0.2 (0.07-0.3) |
| COPD | 1.0 (0.9-1.1) | 1.4 (1.3-1.6) | 0.9 (0.7-1.1) | 1.5 (1.2-1.8) | 1.0 (0.9-1.2) | 1.5 (1.3-1.7) | 0.8 (0.6-1.2) | 1.0 (0.7-1.3) |
| Cirrhosis | 0.2 (0.2-0.3) | 0.4 (0.3-0.5) | 0.3 (0.2-0.4) | 0.5 (0.4-0.7) | 0.2 (0. 2-0.3) | 0.4 (0.3-0.5) | 0.1 (0.02-0.2) | 0.2 (0.08-0.4) |
| Renal | 0.4 (0.4-0.5) | 0.7 (0.6-0.8) | 0.5 (0.3-0.7) | 0.8 (0.6-1.0) | 0.5 (0.4-0.5) | 0.7 (0.6-0.8) | 0.3 (0.2-0.6) | 0.5 (0.3-0.7) |
| Accidents | 0.4 (0.3-0.5) | 0.6 (0.5-0.7) | 0.3 (0.2-0.5) | 0.5 (0.3-0.7) | 0.4 (0.3-0.5) | 0.6 (0.5-0.7) | 0.6 (0.4-0.9) | 0.8 (0.6-1.1) |
| Other | 3.4 (3.2-3.6) | 4.9 (4.6-5.1) | 3.0 (2.6-4.5) | 4.6 (4.1-5.1) | 3.5 (3.2-3.7) | 5.1 (4.8-5.4) | 3.6 (3.0-4.2) | 4.4 (3.8-5.1) |
The rates of each COD differed significantly according to MDS risk group, except for death due to accidents (P = 0.4).