Association of genotype and DSST T-score, adjusted for factors that were associated with genotype severity
| Covariates (X) . | Model adjusted for X . | VIF* . |
|---|---|---|
| β (SE); P . | ||
| Unadjusted | −7.42 (2.48); .004 | 1.00 |
| Hemoglobin | −7.10 (3.05); .02 | 1.50 |
| Ferritin | −7.62 (2.67); .006 | 1.05 |
| DBP | −7.97 (2.63); .003 | 1.07 |
| MAP | −8.14 (2.68); .003 | 1.09 |
| Hydroxyurea use | −7.54 (2.58); .004 | 1.07 |
| Stroke/SCI history | −6.63 (2.42); .008 | 1.02 |
| Fully adjusted† | −8.70 (3.47); .01 | 7.76 |
| Covariates (X) . | Model adjusted for X . | VIF* . |
|---|---|---|
| β (SE); P . | ||
| Unadjusted | −7.42 (2.48); .004 | 1.00 |
| Hemoglobin | −7.10 (3.05); .02 | 1.50 |
| Ferritin | −7.62 (2.67); .006 | 1.05 |
| DBP | −7.97 (2.63); .003 | 1.07 |
| MAP | −8.14 (2.68); .003 | 1.09 |
| Hydroxyurea use | −7.54 (2.58); .004 | 1.07 |
| Stroke/SCI history | −6.63 (2.42); .008 | 1.02 |
| Fully adjusted† | −8.70 (3.47); .01 | 7.76 |
DSST T-scores are adjusted for age, race, sex, and education. The β and P values are for the variable “genotype” (severe vs moderate-severe), for the model of “genotype” predicting DSST score, adjusted for the covariate reported in the corresponding row of the table.
SE, standard error.
VIF indicates variance inflation factor of genotype in unadjusted and adjusted models.
Fully adjusted model includes genotype, hemoglobin, ferritin, DBP, MAP, hydroxyurea use, and stroke/SCI history as predictors.