Multivariable analysis for TTF and OS.
| Variable . | TTF . | OS . | ||||
|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Model 1 | ||||||
| Transfusion dependence: Y vs N | 2.07 | 1.18-3.64 | .01 | 2.04 | 1.02-4.11 | .05 |
| ASXL1/EZH2: Y vs N | 2.05 | 1.16-3.61 | .01 | 2.46 | 1.23-4.92 | .01 |
| Model 2 | ||||||
| DIPSS score: int-2 vs int-1 | 1.57 | 0.71-3.49 | .27 | 1.40 | 0.53-3.69 | .50 |
| DIPSS score: high vs int-1 | 2.79 | 1.24-6.31 | .01 | 3.00 | 1.12-8.03 | .03 |
| ASXL1/EZH2 mutation: Y vs N | 1.87 | 1.05-3.33 | .04 | 2.28 | 1.13-4.61 | .02 |
| Variable . | TTF . | OS . | ||||
|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Model 1 | ||||||
| Transfusion dependence: Y vs N | 2.07 | 1.18-3.64 | .01 | 2.04 | 1.02-4.11 | .05 |
| ASXL1/EZH2: Y vs N | 2.05 | 1.16-3.61 | .01 | 2.46 | 1.23-4.92 | .01 |
| Model 2 | ||||||
| DIPSS score: int-2 vs int-1 | 1.57 | 0.71-3.49 | .27 | 1.40 | 0.53-3.69 | .50 |
| DIPSS score: high vs int-1 | 2.79 | 1.24-6.31 | .01 | 3.00 | 1.12-8.03 | .03 |
| ASXL1/EZH2 mutation: Y vs N | 1.87 | 1.05-3.33 | .04 | 2.28 | 1.13-4.61 | .02 |
ASXL1/EZH2 was tested in 2 models against transfusion dependence and DIPSS.
int-1, intermediate-1; int-2, intermediate-2; N, no; Y, yes.