The genes and regions targeted by the sequencing panel
| Gene . | Region . |
|---|---|
| Intrinsic apoptosis* | |
| BCL2A1 (A1) | All exons and splice sites, 3′ and 5′ UTR regions |
| BAD | |
| BAK1 | |
| BAX | |
| BCL2 | |
| BCL2L2 (BCLW) | |
| BCL2L1 (BCLX) | |
| BCL2L11 (BIM) | |
| BMF | |
| MCL1 | |
| Hematologic malignancy* | |
| ASXL1 | Exon 12 |
| CBL | Exons 8 and 9 |
| CDKN2A | All exons |
| GATA2 | Exon 5 |
| IDH1 | Exon 4 |
| IDH2 | Exon 5 |
| IKZF1 | Exons 3-6 and 3′ UTR |
| KRAS | Exon 2 |
| NRAS | Exon 2 |
| PAX5 | Exon 3 |
| PDGFRA | Exons 12, 14, 18 |
| RB1 | All exons |
| RUNX1 | All exons |
| TET2 | All exons |
| TP53 | All exons |
| WT1 | All exons |
| Variant association* | |
| IFNG | rs2069705 |
| IL15 | rs10519613 and rs17007695 |
| MDM2 | rs2279744 |
| PTCH1 | rs41316950 |
| SMO | rs1061285 |
| Drug metabolism* | |
| ABCG2 | rs2231142 |
| CYP2C19 | rs3758581 |
| CYP3A5 | rs776746 |
| GSTM1 | rs74837985 |
| NAT2 | rs1799930 |
| SLC22A1 (OCT1) | rs628031 and rs35191146 |
| SLCO1B1 | rs4149056 |
| UGT2B7 | rs7668258 |
| Gene . | Region . |
|---|---|
| Intrinsic apoptosis* | |
| BCL2A1 (A1) | All exons and splice sites, 3′ and 5′ UTR regions |
| BAD | |
| BAK1 | |
| BAX | |
| BCL2 | |
| BCL2L2 (BCLW) | |
| BCL2L1 (BCLX) | |
| BCL2L11 (BIM) | |
| BMF | |
| MCL1 | |
| Hematologic malignancy* | |
| ASXL1 | Exon 12 |
| CBL | Exons 8 and 9 |
| CDKN2A | All exons |
| GATA2 | Exon 5 |
| IDH1 | Exon 4 |
| IDH2 | Exon 5 |
| IKZF1 | Exons 3-6 and 3′ UTR |
| KRAS | Exon 2 |
| NRAS | Exon 2 |
| PAX5 | Exon 3 |
| PDGFRA | Exons 12, 14, 18 |
| RB1 | All exons |
| RUNX1 | All exons |
| TET2 | All exons |
| TP53 | All exons |
| WT1 | All exons |
| Variant association* | |
| IFNG | rs2069705 |
| IL15 | rs10519613 and rs17007695 |
| MDM2 | rs2279744 |
| PTCH1 | rs41316950 |
| SMO | rs1061285 |
| Drug metabolism* | |
| ABCG2 | rs2231142 |
| CYP2C19 | rs3758581 |
| CYP3A5 | rs776746 |
| GSTM1 | rs74837985 |
| NAT2 | rs1799930 |
| SLC22A1 (OCT1) | rs628031 and rs35191146 |
| SLCO1B1 | rs4149056 |
| UGT2B7 | rs7668258 |
The genomic coordinates of the targeted regions are provided in supplemental Table 1.