Multivariable analysis
| . | OS . | RFS . | Relapse . | NRM . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | HR* . | 95% CI . | P value . | HR* . | 95% CI . | P value . | HR* . | 95% CI . | P value . | HR* . | 95% CI . | P value . |
| Donor source | ||||||||||||
| MUD 10/10 vs MRD | 0.99 | 0.90-1.09 | .89 | 0.93 | 0.85-1.02 | .11 | 0.74 | 0.66-0.83 | <.001 | 1.39 | 1.19-1.62 | <.001 |
| MUD 9/10 vs MRD | 1.23 | 1.07-1.42 | .005 | 1.17 | 1.02-1.34 | .023 | 0.93 | 0.78-1.11 | .44 | 1.77 | 1.43-2.20 | <.001 |
| UCB vs MRD | 1.54 | 1.31-1.81 | <.001 | 1.37 | 1.17-1.60 | <.001 | 0.96 | 0.77-1.19 | .69 | 2.41 | 1.92-3.04 | <.001 |
| Haplo vs MRD | 1.12 | 0.89-1.40 | .34 | 1.00 | 0.81-1.25 | .97 | 0.60 | 0.44-0.84 | .001 | 1.98 | 1.47-2.68 | <.001 |
| Age† | 1.17 | 1.13-1.21 | <.001 | 1.13 | 1.09-1.16 | <.001 | 1.07 | 1.02-1.12 | .002 | 1.22 | 1.16-1.29 | <.001 |
| Poor-risk cytogenetics (yes vs no) | 1.31 | 1.20-1.44 | <.001 | 1.36 | 1.25-1.48 | <.001 | 1.66 | 1.49-1.85 | <.001 | 0.95 | 0.82-1.09 | .47 |
| Secondary AML (yes vs no) | 1.35 | 1.23-1.48 | <.001 | 1.33 | 1.22-1.46 | <.001 | 1.28 | 1.14-1.44 | <.001 | 1.40 | 1.21-1.61 | <.001 |
| Time from diagnosis to transplant‡ | 0.99 | 0.98-1.00 | .095 | 0.99 | 0.98-1.00 | .039 | 0.97 | 0.96-0.99 | .002 | 1.00 | 0.99-1.02 | .69 |
| Year of transplant§ | 0.96 | 0.85-1.09 | .50 | 0.95 | 0.84-1.06 | .36 | 1.03 | 0.89-1.19 | .68 | 0.80 | 0.66-0.98 | .029 |
| Conditioning (RIC vs MAC) | 0.98 | 0.90-1.06 | .59 | 1.03 | 0.95-1.12 | .42 | 1.23 | 1.11-1.37 | <.001 | 0.78 | 0.68-0.89 | <.001 |
| In vivo T-cell depletion (yes vs no) | 1.04 | 0.95-1.13 | .37 | 1.06 | 0.98-1.15 | .15 | 1.13 | 1.02-1.25 | .023 | 0.94 | 0.82-1.07 | .35 |
| . | OS . | RFS . | Relapse . | NRM . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | HR* . | 95% CI . | P value . | HR* . | 95% CI . | P value . | HR* . | 95% CI . | P value . | HR* . | 95% CI . | P value . |
| Donor source | ||||||||||||
| MUD 10/10 vs MRD | 0.99 | 0.90-1.09 | .89 | 0.93 | 0.85-1.02 | .11 | 0.74 | 0.66-0.83 | <.001 | 1.39 | 1.19-1.62 | <.001 |
| MUD 9/10 vs MRD | 1.23 | 1.07-1.42 | .005 | 1.17 | 1.02-1.34 | .023 | 0.93 | 0.78-1.11 | .44 | 1.77 | 1.43-2.20 | <.001 |
| UCB vs MRD | 1.54 | 1.31-1.81 | <.001 | 1.37 | 1.17-1.60 | <.001 | 0.96 | 0.77-1.19 | .69 | 2.41 | 1.92-3.04 | <.001 |
| Haplo vs MRD | 1.12 | 0.89-1.40 | .34 | 1.00 | 0.81-1.25 | .97 | 0.60 | 0.44-0.84 | .001 | 1.98 | 1.47-2.68 | <.001 |
| Age† | 1.17 | 1.13-1.21 | <.001 | 1.13 | 1.09-1.16 | <.001 | 1.07 | 1.02-1.12 | .002 | 1.22 | 1.16-1.29 | <.001 |
| Poor-risk cytogenetics (yes vs no) | 1.31 | 1.20-1.44 | <.001 | 1.36 | 1.25-1.48 | <.001 | 1.66 | 1.49-1.85 | <.001 | 0.95 | 0.82-1.09 | .47 |
| Secondary AML (yes vs no) | 1.35 | 1.23-1.48 | <.001 | 1.33 | 1.22-1.46 | <.001 | 1.28 | 1.14-1.44 | <.001 | 1.40 | 1.21-1.61 | <.001 |
| Time from diagnosis to transplant‡ | 0.99 | 0.98-1.00 | .095 | 0.99 | 0.98-1.00 | .039 | 0.97 | 0.96-0.99 | .002 | 1.00 | 0.99-1.02 | .69 |
| Year of transplant§ | 0.96 | 0.85-1.09 | .50 | 0.95 | 0.84-1.06 | .36 | 1.03 | 0.89-1.19 | .68 | 0.80 | 0.66-0.98 | .029 |
| Conditioning (RIC vs MAC) | 0.98 | 0.90-1.06 | .59 | 1.03 | 0.95-1.12 | .42 | 1.23 | 1.11-1.37 | <.001 | 0.78 | 0.68-0.89 | <.001 |
| In vivo T-cell depletion (yes vs no) | 1.04 | 0.95-1.13 | .37 | 1.06 | 0.98-1.15 | .15 | 1.13 | 1.02-1.25 | .023 | 0.94 | 0.82-1.07 | .35 |
CI, confidence interval; NRM, time as RFS with event death in first CR and censored at relapse; relapse, time as RFS and with event relapse and censored at death in first CR.
The HRs are the estimates of the effect of covariates for each outcome parameter, adjusted for donor, age, poor-risk cytogenetics, secondary AML, time from diagnosis to transplant, year of transplant, conditioning type, and in vivo T-cell depletion.
Linear with estimates of 10-y difference.
Linear with estimates of 1-mo difference.
Linear with estimates of 10-y difference.