Comparison of genetic alterations between patients with low and high lncRNA scores
| Gene . | No. of specimens examined . | Mutated (%) . | P . | ||
|---|---|---|---|---|---|
| Total . | Low lncRNA score . | High lncRNA score . | |||
| SF3B1 | 175 | 29 (16.6) | 21 (23.9) | 8 (9.2) | .014* |
| FLT3/ITD | 174 | 1 (0.6) | 0 (0) | 1 (1.2) | .494 |
| NRAS/KRAS | 175 | 5 (2.9) | 1 (1.1) | 4 (4.6) | .211 |
| RUNX1 | 172 | 25 (14.5) | 4 (4.6) | 21 (24.7) | <.001* |
| MLL/PTD | 173 | 1 (0.6) | 0 (0) | 1 (1.2) | .497 |
| IDH1/2 | 175 | 4 (2.3) | 0 (0) | 4 (4.6) | .059 |
| ASXL1 | 173 | 36 (20.8) | 9 (10.2) | 27 (31.8) | .001* |
| TET2 | 175 | 22 (12.6) | 10 (11.4) | 12 (13.8) | .655 |
| DNMT3A | 175 | 25 (14.3) | 8 (9.1) | 17 (19.5) | .054 |
| TP53 | 174 | 12 (6.9) | 1 (1.1) | 11 (12.8) | .002* |
| SETBP1 | 175 | 4 (2.3) | 0 (0) | 4 (4.6) | .059 |
| EZH2 | 176 | 10 (5.7) | 4 (4.5) | 6 (6.8) | .538 |
| U2AF1 | 175 | 14 (8) | 7 (8) | 7 (8) | >.999 |
| SRSF2 | 175 | 24 (13.7) | 6 (6.8) | 18 (20.7) | .009* |
| ZRSR2 | 171 | 15 (8.8) | 1 (1.2) | 14 (16.3) | .001* |
| Gene . | No. of specimens examined . | Mutated (%) . | P . | ||
|---|---|---|---|---|---|
| Total . | Low lncRNA score . | High lncRNA score . | |||
| SF3B1 | 175 | 29 (16.6) | 21 (23.9) | 8 (9.2) | .014* |
| FLT3/ITD | 174 | 1 (0.6) | 0 (0) | 1 (1.2) | .494 |
| NRAS/KRAS | 175 | 5 (2.9) | 1 (1.1) | 4 (4.6) | .211 |
| RUNX1 | 172 | 25 (14.5) | 4 (4.6) | 21 (24.7) | <.001* |
| MLL/PTD | 173 | 1 (0.6) | 0 (0) | 1 (1.2) | .497 |
| IDH1/2 | 175 | 4 (2.3) | 0 (0) | 4 (4.6) | .059 |
| ASXL1 | 173 | 36 (20.8) | 9 (10.2) | 27 (31.8) | .001* |
| TET2 | 175 | 22 (12.6) | 10 (11.4) | 12 (13.8) | .655 |
| DNMT3A | 175 | 25 (14.3) | 8 (9.1) | 17 (19.5) | .054 |
| TP53 | 174 | 12 (6.9) | 1 (1.1) | 11 (12.8) | .002* |
| SETBP1 | 175 | 4 (2.3) | 0 (0) | 4 (4.6) | .059 |
| EZH2 | 176 | 10 (5.7) | 4 (4.5) | 6 (6.8) | .538 |
| U2AF1 | 175 | 14 (8) | 7 (8) | 7 (8) | >.999 |
| SRSF2 | 175 | 24 (13.7) | 6 (6.8) | 18 (20.7) | .009* |
| ZRSR2 | 171 | 15 (8.8) | 1 (1.2) | 14 (16.3) | .001* |
Statistically significant if P < .05.