Table 4.

Cox regression of cardiovascular events and cardiovascular event-free survival for ESA-treated vs untreated patients, adjusted for confounders

HR95% CIP
Cardiovascular event    
 Unadjusted    
  ESA treatment 1.28 0.68-2.42 .445 
 Adjusted*    
  ESA treatment 1.24 0.66-2.34 .507 
  Presence of another cytopenia 1.92 1.07-3.42 .028 
Cardiovascular event or death    
 Unadjusted    
  ESA treatment 1.21 0.88-1.66 .234 
 Adjusted    
  ESA treatment 0.94 0.67-1.31 .693 
  Presence of another cytopenia 2.06 1.54-2.75 < .001 
  Hemoglobin, g/L 0.98 0.97-0.99 < .001 
  Age, years 1.03 1.01-1.06 .001 
  Male sex 1.55 1.15-2.08 .004 
  Comorbidity index 1.13 1.03-1.23 .006 
HR95% CIP
Cardiovascular event    
 Unadjusted    
  ESA treatment 1.28 0.68-2.42 .445 
 Adjusted*    
  ESA treatment 1.24 0.66-2.34 .507 
  Presence of another cytopenia 1.92 1.07-3.42 .028 
Cardiovascular event or death    
 Unadjusted    
  ESA treatment 1.21 0.88-1.66 .234 
 Adjusted    
  ESA treatment 0.94 0.67-1.31 .693 
  Presence of another cytopenia 2.06 1.54-2.75 < .001 
  Hemoglobin, g/L 0.98 0.97-0.99 < .001 
  Age, years 1.03 1.01-1.06 .001 
  Male sex 1.55 1.15-2.08 .004 
  Comorbidity index 1.13 1.03-1.23 .006 
*

Adjusted for presence of a cytopenia.

Adjusted for presence of a cytopenia, hemoglobin, age, sex, and comorbidity index.

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