Factors associated with OS among patients with PCNSL who received upfront treatment with chemotherapy or radiation
| Variable . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|
| Treatment modality | |||
| Multiagent chemotherapy | Reference | <.0001 | |
| Single-agent chemotherapy | 1.35 | 1.26-1.45 | |
| Radiation therapy alone | 2.17 | 1.98-2.39 | |
| Age group, y | |||
| 18-50 | Reference | <.0001 | |
| 51-60 | 1.63 | 1.43-1.86 | |
| 61-70 | 2.13 | 1.87-2.42 | |
| 71-80 | 2.98 | 2.59-3.43 | |
| >80 | 3.88 | 3.29-4.57 | |
| Sex | |||
| Male | Reference | .003 | |
| Female | 0.91 | 0.85-0.97 | |
| Race | |||
| White non-Hispanic | Reference | .09 | |
| Black | 0.91 | 0.77-1.07 | |
| Asian/other | 0.85 | 0.72-1.01 | |
| Charlson-Deyo index | |||
| 0 | Reference | <.0001 | |
| 1 | 1.11 | 1.03-1.20 | |
| ≥2 | 1.25 | 1.14-1.38 | |
| Health insurance | |||
| Private insurance | Reference | .0003 | |
| Not insured | 1.25 | 1.04-1.51 | |
| Medicaid | 1.26 | 1.08-1.46 | |
| Medicare | 1.16 | 1.06-1.27 | |
| Other | 1.34 | 1.02-1.76 | |
| Median income* | |||
| <$30 000 | Reference | .0001 | |
| $30 000-$35 999 | 0.93 | 0.85-1.03 | |
| $36 000-$45 999 | 0.86 | 0.78-0.95 | |
| ≥$46 000 | 0.81 | 0.74-0.89 | |
| Histology | |||
| DLBCL | Reference | .027 | |
| PCNSL, NOS | 0.91 | 0.84-0.99 | |
| Anatomical location | |||
| Brain | Reference | <.0001 | |
| Spinal cord | 0.57 | 0.49-0.67 | |
| Unspecified | 0.76 | 0.68-0.85 | |
| Type of cancer program | |||
| Community | Reference | .009 | |
| Academic program | 0.92 | 0.86-0.98 |
| Variable . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|
| Treatment modality | |||
| Multiagent chemotherapy | Reference | <.0001 | |
| Single-agent chemotherapy | 1.35 | 1.26-1.45 | |
| Radiation therapy alone | 2.17 | 1.98-2.39 | |
| Age group, y | |||
| 18-50 | Reference | <.0001 | |
| 51-60 | 1.63 | 1.43-1.86 | |
| 61-70 | 2.13 | 1.87-2.42 | |
| 71-80 | 2.98 | 2.59-3.43 | |
| >80 | 3.88 | 3.29-4.57 | |
| Sex | |||
| Male | Reference | .003 | |
| Female | 0.91 | 0.85-0.97 | |
| Race | |||
| White non-Hispanic | Reference | .09 | |
| Black | 0.91 | 0.77-1.07 | |
| Asian/other | 0.85 | 0.72-1.01 | |
| Charlson-Deyo index | |||
| 0 | Reference | <.0001 | |
| 1 | 1.11 | 1.03-1.20 | |
| ≥2 | 1.25 | 1.14-1.38 | |
| Health insurance | |||
| Private insurance | Reference | .0003 | |
| Not insured | 1.25 | 1.04-1.51 | |
| Medicaid | 1.26 | 1.08-1.46 | |
| Medicare | 1.16 | 1.06-1.27 | |
| Other | 1.34 | 1.02-1.76 | |
| Median income* | |||
| <$30 000 | Reference | .0001 | |
| $30 000-$35 999 | 0.93 | 0.85-1.03 | |
| $36 000-$45 999 | 0.86 | 0.78-0.95 | |
| ≥$46 000 | 0.81 | 0.74-0.89 | |
| Histology | |||
| DLBCL | Reference | .027 | |
| PCNSL, NOS | 0.91 | 0.84-0.99 | |
| Anatomical location | |||
| Brain | Reference | <.0001 | |
| Spinal cord | 0.57 | 0.49-0.67 | |
| Unspecified | 0.76 | 0.68-0.85 | |
| Type of cancer program | |||
| Community | Reference | .009 | |
| Academic program | 0.92 | 0.86-0.98 |
NOS, not otherwise specified.
In the patient’s zip code of residence, according to the 2012 American Community Survey data and grouped into population quartiles.