Summary of virus reactivation and immune recovery after hematopoietic stem cell transplant
| Patient ID . | CMV (D,R) . | EBV (D,R) . | CD4 >100 recovery . | CD4 >200 recovery . | HHV-6 reactivation day of onset . | HHV-6 max level . | Last day of HHV-6 reactivation . | CMV reactivation and day of onset . | CMV max level . | Last day of CMV reactivation . | EBV reactivation day of onset . | EBV max level . | Last day of EBV reactivation . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | −/− | +/− | 132 | 176 | 8 | 7 300 | 400 | None | — | — | None | — | — |
| 2 | −/+ | +/+ | 92 | 96 | 33 | 400 | 41 | 68 | 46 500 | * | 26 | 50 018 | 98 |
| 3 | −/− | +/+ | 148 | 169 | 14 | 1 400 | 27 | None | — | — | 17 | 5 573 | 31 |
| 4 | +/− | +/+ | 148 | 149 | None | — | — | None | — | — | None | — | — |
| 5 | +/+ | +/+ | 59 | 59 | 59 | 522 | 140 | 10 | 85 500 | 192 | 24 | 89 250 | 59 |
| 6 | +/− | +/− | 342 | 452 | 17 | 31 800 | 153 | None | — | — | None | — | — |
| 7 | −/− | +/+ | 124 | 163 | 26 | 287 | 34 | None | — | — | None | — | — |
| 8 | +/− | +/+ | 153 | 163 | 65 | 76 | 90 | None | — | — | 139 | 1 095 | 365 |
| 9 | +/+ | +/+ | 136 | 167 | 24 | 98 | 97 | 35 | <137 | 115 | None | — | — |
| 10 | −/− | −/− | 131 | 146 | 32 | 54 075 | † | None | — | — | None | — | — |
| Patient ID . | CMV (D,R) . | EBV (D,R) . | CD4 >100 recovery . | CD4 >200 recovery . | HHV-6 reactivation day of onset . | HHV-6 max level . | Last day of HHV-6 reactivation . | CMV reactivation and day of onset . | CMV max level . | Last day of CMV reactivation . | EBV reactivation day of onset . | EBV max level . | Last day of EBV reactivation . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | −/− | +/− | 132 | 176 | 8 | 7 300 | 400 | None | — | — | None | — | — |
| 2 | −/+ | +/+ | 92 | 96 | 33 | 400 | 41 | 68 | 46 500 | * | 26 | 50 018 | 98 |
| 3 | −/− | +/+ | 148 | 169 | 14 | 1 400 | 27 | None | — | — | 17 | 5 573 | 31 |
| 4 | +/− | +/+ | 148 | 149 | None | — | — | None | — | — | None | — | — |
| 5 | +/+ | +/+ | 59 | 59 | 59 | 522 | 140 | 10 | 85 500 | 192 | 24 | 89 250 | 59 |
| 6 | +/− | +/− | 342 | 452 | 17 | 31 800 | 153 | None | — | — | None | — | — |
| 7 | −/− | +/+ | 124 | 163 | 26 | 287 | 34 | None | — | — | None | — | — |
| 8 | +/− | +/+ | 153 | 163 | 65 | 76 | 90 | None | — | — | 139 | 1 095 | 365 |
| 9 | +/+ | +/+ | 136 | 167 | 24 | 98 | 97 | 35 | <137 | 115 | None | — | — |
| 10 | −/− | −/− | 131 | 146 | 32 | 54 075 | † | None | — | — | None | — | — |
HHV-6, CMV, and EBV maximum levels are in maximum copy number (copies/microliter) by real-time polymerase chain reaction in blood.
—, Not applicable; (D,R), viral serology of donor (D) and recipient (R).
Patient had reactivation at the time of death.
Patient has reactivation at time of last follow-up.