Recipient and donor characteristics
| Patient ID . | Age at HSCT (y) . | Sex . | Type of sickle Hgb . | Coexisting conditions and indications for HSCT . | Donor relationship (match and mismatched loci . | Donor sickle cell trait (yes/no) . | Donor blood type . | Recipient blood type . |
|---|---|---|---|---|---|---|---|---|
| 1 | 13 | F | SS | Recurrent VOC, acute chest syndrome, osteonecrosis | Father (7/10, HLA-A,B,C) | Yes | O+ | B+ |
| 2 | 15 | F | SS | Recurrent VOC, red cell alloimmunization | Half-brother (5/10, HLA-A,B,C,DR,DQ) | Yes | O+ | A+ |
| 3 | 13 | M | Sβ0thal | Recurrent VOC, Kostmann’s neutropenia | Unrelated donor (10/10) | No | O+ | AB+ |
| 4 | 8 | F | SS | Conditional TCD, nocturnal hypoxia, narrowing of CNS arteries on MRA | Sister (9/10, HLA-A) | Yes | A+ | B+ |
| 5 | 5 | F | SS | Stroke, narrowing of CNS arteries on MRA | Unrelated donor (9/10, HLA-DQ) | No | O+ | O+ |
| 6 | 17 | M | SS | Recurrent VOC, acute chest syndrome | Mother (5/10, HLA-A,B,C,DR,DQ) | Yes | O+ | B+ |
| 7 | 19 | M | SS | Stroke, narrowing of CNS arteries on MRA | Sister (6/10, HLA-A,B,C,DR) | Yes | O+ | O+ |
| 8 | 18 | M | SS | Recurrent VOC | Half-sister (6/10, HLA-A,B,C,DR) | No | A+ | B+ |
| 9 | 12 | M | SS | Acute chest syndrome | Uncle (5/10, HLA-A,B,C,DR,DQ) | No | AB+ | O+ |
| 10 | 23 | F | SS | Recurrent VOC, osteonecrosis | Brother (6/10 HLA-A,B,DR,DQ) | Yes | AB+ | AB+ |
| Patient ID . | Age at HSCT (y) . | Sex . | Type of sickle Hgb . | Coexisting conditions and indications for HSCT . | Donor relationship (match and mismatched loci . | Donor sickle cell trait (yes/no) . | Donor blood type . | Recipient blood type . |
|---|---|---|---|---|---|---|---|---|
| 1 | 13 | F | SS | Recurrent VOC, acute chest syndrome, osteonecrosis | Father (7/10, HLA-A,B,C) | Yes | O+ | B+ |
| 2 | 15 | F | SS | Recurrent VOC, red cell alloimmunization | Half-brother (5/10, HLA-A,B,C,DR,DQ) | Yes | O+ | A+ |
| 3 | 13 | M | Sβ0thal | Recurrent VOC, Kostmann’s neutropenia | Unrelated donor (10/10) | No | O+ | AB+ |
| 4 | 8 | F | SS | Conditional TCD, nocturnal hypoxia, narrowing of CNS arteries on MRA | Sister (9/10, HLA-A) | Yes | A+ | B+ |
| 5 | 5 | F | SS | Stroke, narrowing of CNS arteries on MRA | Unrelated donor (9/10, HLA-DQ) | No | O+ | O+ |
| 6 | 17 | M | SS | Recurrent VOC, acute chest syndrome | Mother (5/10, HLA-A,B,C,DR,DQ) | Yes | O+ | B+ |
| 7 | 19 | M | SS | Stroke, narrowing of CNS arteries on MRA | Sister (6/10, HLA-A,B,C,DR) | Yes | O+ | O+ |
| 8 | 18 | M | SS | Recurrent VOC | Half-sister (6/10, HLA-A,B,C,DR) | No | A+ | B+ |
| 9 | 12 | M | SS | Acute chest syndrome | Uncle (5/10, HLA-A,B,C,DR,DQ) | No | AB+ | O+ |
| 10 | 23 | F | SS | Recurrent VOC, osteonecrosis | Brother (6/10 HLA-A,B,DR,DQ) | Yes | AB+ | AB+ |
CNS, central nervous system; F female; Hgb, hemoglobin; HLA, human leukocyte antigen; M, male; MRA, magnetic resonance angiogram; Sβ0thal, hemoglobin S-β0 thalassemia; SS, homozygous hemoglobin S; TCD, transcranial Doppler ultrasound; VOC, vaso-occlusive crisis.