Risk factors for major bleeding in all patients by 30 days (8 events)
| . | Univariate odds . | P . | Multivariate odds . | P . |
|---|---|---|---|---|
| Patient factors | ||||
| Age (Δ10 y) | 1.15 | .65 | ||
| Weight (Δ10 kg) | 0.83 | .37 | ||
| Sex (male vs female) | 1.01 | .99 | ||
| Ethnicity (white vs nonwhite) | 0.62 | .67 | ||
| Disease (lymphoma vs myeloma) | 1.17 | .85 | ||
| Treatment factors | ||||
| Conditioning chemo (melphalan) | 1.00 | |||
| BEAM | 1.29 | .78 | ||
| H-TBI/Cytoxan+/− VP-16 | 0.61 | .69 | ||
| Other | 1.93 | .52 | ||
| Anticoagulation (discontinuation) | 1.00 | |||
| LMWH | 0.29 | .29 | ||
| Unfractionated heparin | 1.96 | .39 | ||
| Proposed platelet threshold (Δ10 × 103/μL) | 0.99 | .95 | ||
| Average platelet AUC (Δ10 × 103/μL) | 1.01 | .97 | ||
| Thrombocytopenia duration (Δ1 d) | 1.00 | .90 | ||
| Total length of stay (Δ1 d) | 1.02 | .11 | ||
| Preconditioning laboratory tests | ||||
| WBC (Δ1 × 109/L) | 1.00 | .07 | ||
| Hemoglobin (Δ1 g/dL) | 0.47 | .02 | ||
| Platelet (Δ10 × 103/μL) | 1.00 | .35 | ||
| Creatinine (Δ1 mg/dL) | 7.92 | .05 | 14.49 | .03 |
| Bilirubin (Δ1 mg/dL) | 12.16 | <.01 | 19.63 | <.01 |
| LDH (Δ100 U/L) | 1.66 | .01 | ||
| PT (Δ1 s) | 2.48 | .01 | 2.96 | <.01 |
| PTT (Δ1 s) | 1.01 | .75 |
| . | Univariate odds . | P . | Multivariate odds . | P . |
|---|---|---|---|---|
| Patient factors | ||||
| Age (Δ10 y) | 1.15 | .65 | ||
| Weight (Δ10 kg) | 0.83 | .37 | ||
| Sex (male vs female) | 1.01 | .99 | ||
| Ethnicity (white vs nonwhite) | 0.62 | .67 | ||
| Disease (lymphoma vs myeloma) | 1.17 | .85 | ||
| Treatment factors | ||||
| Conditioning chemo (melphalan) | 1.00 | |||
| BEAM | 1.29 | .78 | ||
| H-TBI/Cytoxan+/− VP-16 | 0.61 | .69 | ||
| Other | 1.93 | .52 | ||
| Anticoagulation (discontinuation) | 1.00 | |||
| LMWH | 0.29 | .29 | ||
| Unfractionated heparin | 1.96 | .39 | ||
| Proposed platelet threshold (Δ10 × 103/μL) | 0.99 | .95 | ||
| Average platelet AUC (Δ10 × 103/μL) | 1.01 | .97 | ||
| Thrombocytopenia duration (Δ1 d) | 1.00 | .90 | ||
| Total length of stay (Δ1 d) | 1.02 | .11 | ||
| Preconditioning laboratory tests | ||||
| WBC (Δ1 × 109/L) | 1.00 | .07 | ||
| Hemoglobin (Δ1 g/dL) | 0.47 | .02 | ||
| Platelet (Δ10 × 103/μL) | 1.00 | .35 | ||
| Creatinine (Δ1 mg/dL) | 7.92 | .05 | 14.49 | .03 |
| Bilirubin (Δ1 mg/dL) | 12.16 | <.01 | 19.63 | <.01 |
| LDH (Δ100 U/L) | 1.66 | .01 | ||
| PT (Δ1 s) | 2.48 | .01 | 2.96 | <.01 |
| PTT (Δ1 s) | 1.01 | .75 |
Univariate logistic regression models were built to test the association between major bleeding and all relevant covariates to determine potential predictors of major bleeding. Multivariate logistic regression model using a stepwise estimation by backward and forward selection was then generated from variables with P < .10 from the univariate model. Preconditioning creatinine, bilirubin, and prothrombin time were independently predictive of major bleeding in the final model.