Correlation of molecular markers with diverse cytogenetic subgroups in AML.
| Molecular marker . | Correlation to cytogenetic subgroup . | Frequency of molecular alteration, % . |
|---|---|---|
| KIT mutation | t(8;21)/RUNX1/RUNX1T1 inv(16)/t(16;16)/CBFB-MYH11 | ~25 ~25 |
| FLT3-ITD | t(15;17)/PML-RARA t(6;9)/DEK-CAN | ~40 ~90 |
| NRAS mutation | inv(16)/t(16;16)/CBFB-MYH11 inv(3)/t(3;3) | ~35 ~25 |
| RUNX1-mutation TP53 mutation/deletion | Trisomy 13 Complex karyotype, deletion 5q/-5, deletion 7q/-7 | ~80 10–15 |
| Molecular marker . | Correlation to cytogenetic subgroup . | Frequency of molecular alteration, % . |
|---|---|---|
| KIT mutation | t(8;21)/RUNX1/RUNX1T1 inv(16)/t(16;16)/CBFB-MYH11 | ~25 ~25 |
| FLT3-ITD | t(15;17)/PML-RARA t(6;9)/DEK-CAN | ~40 ~90 |
| NRAS mutation | inv(16)/t(16;16)/CBFB-MYH11 inv(3)/t(3;3) | ~35 ~25 |
| RUNX1-mutation TP53 mutation/deletion | Trisomy 13 Complex karyotype, deletion 5q/-5, deletion 7q/-7 | ~80 10–15 |