Table 1.

Mechanisms contributing to the anemia of inflammation/malignancy.

  1. Cytokine-mediated changes

    • Decreased erythropoietin (Epo) production

    • Decreased response of erythroid progenitors to Epo

    • Altered iron metabolism (relative iron deficiency)

  2. Myelosuppressive effects of chemotherapy

    • Suppression of Epo production

    • Direct suppression of marrow function

  3. Blood loss

  4. Nutritional deficiencies

  5. Hemolysis

    • Drug-induced

    • Microangiopathic

    • Autoimmune

 

  1. Cytokine-mediated changes

    • Decreased erythropoietin (Epo) production

    • Decreased response of erythroid progenitors to Epo

    • Altered iron metabolism (relative iron deficiency)

  2. Myelosuppressive effects of chemotherapy

    • Suppression of Epo production

    • Direct suppression of marrow function

  3. Blood loss

  4. Nutritional deficiencies

  5. Hemolysis

    • Drug-induced

    • Microangiopathic

    • Autoimmune

 
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