Table 1. Common variations in CYP2C9 and... | American Society of Hematology

Table 1.

Common variations in CYP2C9 and VKORC1 that affect warfarin dose.

			Prevalence, %
	Name	Variation	Caucasian	African	Asian	Effect on warfarin dose, %
† Data approximate from references ¹³^,¹⁴^,¹⁶^,¹⁷
‡ From reference ¹²
§From references ¹²^,¹⁴
CYP2C9
	*1	Wild-type	81	94	98	Reference
	*2	R144C	13	3	0	− 20†
	*3	I359L	7	2	2	− 30†
VKORC1
	Group A	Haplotypes 1,2‡	37	14	89	−20§
	Group B	Haplotypes 7,8,9	58	49	10	Reference

			Prevalence, %
	Name	Variation	Caucasian	African	Asian	Effect on warfarin dose, %
† Data approximate from references ¹³^,¹⁴^,¹⁶^,¹⁷
‡ From reference ¹²
§From references ¹²^,¹⁴
CYP2C9
	*1	Wild-type	81	94	98	Reference
	*2	R144C	13	3	0	− 20†
	*3	I359L	7	2	2	− 30†
VKORC1
	Group A	Haplotypes 1,2‡	37	14	89	−20§
	Group B	Haplotypes 7,8,9	58	49	10	Reference