Table 3. Who should be tested for... | American Society of Hematology

Table 3.

Who should be tested for paroxysmal nocturnal hemoglobinuria (PNH) and how often?

Once	Repeatedly*
* Initially once every 6 months; then annually
All patients with hemoglobinuria All patients with unexplained hemolysis (increased LDH) All patients with abdominal and cerebral vein thrombosis All patients with thrombocytopenia and macrocytosis or signs of hemolysis	All patients with PNH All patients who have aplastic anemia All patients who have had aplastic anemia (except after bone marrow transplantation All patients with myelodysplastic syndrome (MDS)

Once	Repeatedly*
* Initially once every 6 months; then annually
All patients with hemoglobinuria All patients with unexplained hemolysis (increased LDH) All patients with abdominal and cerebral vein thrombosis All patients with thrombocytopenia and macrocytosis or signs of hemolysis	All patients with PNH All patients who have aplastic anemia All patients who have had aplastic anemia (except after bone marrow transplantation All patients with myelodysplastic syndrome (MDS)