Main randomized studies comparing different durations of anticoagulant therapy after acute unprovoked venous thromboembolism (VTE)
| Study . | Type of VTE . | Duration of treatment . | Number of patients (follow-up) . | VTE recurrences and/or deaths, n (%, 95%CI) . | Major bleeds, n (%) . |
|---|---|---|---|---|---|
| * double-blind study (study was prematurely stopped); all other studies had an open study design | |||||
| Abbreviations: DVT, deep vein thrombosis; PE, pulmonary embolism. | |||||
| Pinède6 | Distal DVT | 6 wk | 105 (1 y) | 3 (3.4) | 1 (1.0) |
| 3 mo | 92 (1 y) | 2 (2.0) | 3 (3.4) | ||
| Schulman9 | DVT | 6 wk | 443 (2 y) | 80 (18.1, 14.5–21.6) | 1 (0.2) |
| 6 mo | 454 (2 y) | 43 (9.5, 6.8–12.2) | 5 (1.1) | ||
| Agnelli11 | DVT | 3 mo | 131 (37 mo) | 21 (15.8) | 0 |
| 1 y | 134 (38 mo) | 21 (15.7) | 4 (3.0) | ||
| Agnelli37 | PE | 6 mo | 161 (33 mo) | 18 (11.2) | 0 |
| 1 y | 165 (35 mo) | 15 (9.1) | 3 (1.8) | ||
| Pinède6 | Proximal DVT or PE | 3 mo | 270 (1 y) | 21 (8.1) | 5 (1.9) |
| 6 m | 269 (1 y) | 23 (8.7) | 7 (2.6) | ||
| Campbell12 | DVT and/or PE | 3 mo | 369 (1 y) | 31 (8.5) | 0 |
| 6 mo | 380 (1 y) | 29 (7.8) | 8 (2.1) | ||
| Kearon10 | DVT* | 3 mo | 83 (10 mo) | 17 (27.4% per y) | 0 |
| continued | 79 (10 mo) | 1 (1.3% per y) | 3 (3.8%) | ||
| Study . | Type of VTE . | Duration of treatment . | Number of patients (follow-up) . | VTE recurrences and/or deaths, n (%, 95%CI) . | Major bleeds, n (%) . |
|---|---|---|---|---|---|
| * double-blind study (study was prematurely stopped); all other studies had an open study design | |||||
| Abbreviations: DVT, deep vein thrombosis; PE, pulmonary embolism. | |||||
| Pinède6 | Distal DVT | 6 wk | 105 (1 y) | 3 (3.4) | 1 (1.0) |
| 3 mo | 92 (1 y) | 2 (2.0) | 3 (3.4) | ||
| Schulman9 | DVT | 6 wk | 443 (2 y) | 80 (18.1, 14.5–21.6) | 1 (0.2) |
| 6 mo | 454 (2 y) | 43 (9.5, 6.8–12.2) | 5 (1.1) | ||
| Agnelli11 | DVT | 3 mo | 131 (37 mo) | 21 (15.8) | 0 |
| 1 y | 134 (38 mo) | 21 (15.7) | 4 (3.0) | ||
| Agnelli37 | PE | 6 mo | 161 (33 mo) | 18 (11.2) | 0 |
| 1 y | 165 (35 mo) | 15 (9.1) | 3 (1.8) | ||
| Pinède6 | Proximal DVT or PE | 3 mo | 270 (1 y) | 21 (8.1) | 5 (1.9) |
| 6 m | 269 (1 y) | 23 (8.7) | 7 (2.6) | ||
| Campbell12 | DVT and/or PE | 3 mo | 369 (1 y) | 31 (8.5) | 0 |
| 6 mo | 380 (1 y) | 29 (7.8) | 8 (2.1) | ||
| Kearon10 | DVT* | 3 mo | 83 (10 mo) | 17 (27.4% per y) | 0 |
| continued | 79 (10 mo) | 1 (1.3% per y) | 3 (3.8%) | ||