Table 2. Mouse models of myelodysplastic... | American Society of Hematology

Table 2.

Mouse models of myelodysplastic syndrome (MDS).

Mouse model	Macrocytic anemia	Neutropenia	Thrombocytopenia	Bone marrow dysplasia	Time to MDS	Evolution to AML	References
NPM +/− mouse	Yes	No	No	Yes	Immediately	Yes	Grisendi et al 2005⁶¹  Sportoletti et al 2008⁶²
NUP98-HOXD13
TG Mouse	Yes	Yes	Yes	Yes	Immediately	Yes	Lin et al 2005⁵⁸
EVI-1 BMT	Yes	No	Yes	Yes	8-10 months	No	Buonamici et al 2004⁵⁹
AML1 mutations							Watanabe-Okochi et al 2008⁵⁷
D171N	Yes	No	Yes	Yes	4-13 months	MDS/AML 13 of 16
S291fsx 300	Yes	Yes	Yes	Yes	4-13 months	MDS/RAEB 2 of 8  MDS/AML 5 0f 8
N-Ras + BCL-2 TG mouse	No	No	Yes	Yes	1 month	MDS/AML 5 of 8	Omidvar et al 2007⁶⁰

Mouse model	Macrocytic anemia	Neutropenia	Thrombocytopenia	Bone marrow dysplasia	Time to MDS	Evolution to AML	References
NPM +/− mouse	Yes	No	No	Yes	Immediately	Yes	Grisendi et al 2005⁶¹  Sportoletti et al 2008⁶²
NUP98-HOXD13
TG Mouse	Yes	Yes	Yes	Yes	Immediately	Yes	Lin et al 2005⁵⁸
EVI-1 BMT	Yes	No	Yes	Yes	8-10 months	No	Buonamici et al 2004⁵⁹
AML1 mutations							Watanabe-Okochi et al 2008⁵⁷
D171N	Yes	No	Yes	Yes	4-13 months	MDS/AML 13 of 16
S291fsx 300	Yes	Yes	Yes	Yes	4-13 months	MDS/RAEB 2 of 8  MDS/AML 5 0f 8
N-Ras + BCL-2 TG mouse	No	No	Yes	Yes	1 month	MDS/AML 5 of 8	Omidvar et al 2007⁶⁰