Genes or pathways that affect hematopoietic stem cell (HSC) behavior.
| Gene/Pathway . | HSC Behavior . | Reference . |
|---|---|---|
| c-myc | HSC/niche | Wilson et al. Genes & Dev 2006 |
| Mef | Self-renewal and quiescence | Lacorazza et al. Cancer Cell 2006 |
| Foxo TFs | Resistance to ROS | Tothova et al. Cell 2007; Miyamoto et al. Cell Stem Cell 2007 |
| Gfi-1 | Proliferation | Hock et al. Nature 2004 |
| GATA-2 | Quiescence | Ling et al. J Exp Med 2004 |
| MAD1 | Proliferation | Walkley et al. Nat Cell Biol 2005 |
| p21 | Quiescence | Cheng et al. Science 2000 |
| p27 | HPC proliferation | Cheng et al. Nat Med 2000 |
| p18 | Self-renewal | Yuan et al. Nat Cell Biol 2004 |
| p16 | Aging | Janzen et al. Nature 2006 |
| Rb | HSC/niche | Walkley et al. Cell 2007 |
| Bmi-1 | Self-renewal and proliferation | Park et al. Nature 2003; Molofsky et al. Nature 2003 |
| HoxB4 | Self-renewal | Krosl et al. Nat Med 2003 |
| Fbw7 | Quiescence | Thompson et al. J Exp Med 2008 |
| Cdc42 | HSC/niche | Yang et al. PNAS 2007 |
| Ang-1/Tie2 | Quiescence | Arai et al. Cell 2004 |
| TPO/MPL | Quiescence | Qian et al. Cell Stem Cell 2007; Yoshihara et al. Cell Stem Cell 2007 |
| PTEN | Self-renewal and quiescence | Zhang et al. Nature 2006; Yilmaz et al. Nature 2006 |
| GSK-3 | HSC maintenance | Trowbridge et al. Nat Med. 2006 |
| LNK | Self-renewal | Seita et al. PNAS 2007 |
| Notch | Self-renewal | Duncan et al. Nature Immunol 2005 |
| Wnt signaling | Self-renewal | Reya et al. Nature 2003 |
| Hedgehog | Self-renewal | Trowbridge et al. PNAS 2006 |
| Zfz | Self-renewal | Galan-Caridad et al. Cell 2007 |
| Gene/Pathway . | HSC Behavior . | Reference . |
|---|---|---|
| c-myc | HSC/niche | Wilson et al. Genes & Dev 2006 |
| Mef | Self-renewal and quiescence | Lacorazza et al. Cancer Cell 2006 |
| Foxo TFs | Resistance to ROS | Tothova et al. Cell 2007; Miyamoto et al. Cell Stem Cell 2007 |
| Gfi-1 | Proliferation | Hock et al. Nature 2004 |
| GATA-2 | Quiescence | Ling et al. J Exp Med 2004 |
| MAD1 | Proliferation | Walkley et al. Nat Cell Biol 2005 |
| p21 | Quiescence | Cheng et al. Science 2000 |
| p27 | HPC proliferation | Cheng et al. Nat Med 2000 |
| p18 | Self-renewal | Yuan et al. Nat Cell Biol 2004 |
| p16 | Aging | Janzen et al. Nature 2006 |
| Rb | HSC/niche | Walkley et al. Cell 2007 |
| Bmi-1 | Self-renewal and proliferation | Park et al. Nature 2003; Molofsky et al. Nature 2003 |
| HoxB4 | Self-renewal | Krosl et al. Nat Med 2003 |
| Fbw7 | Quiescence | Thompson et al. J Exp Med 2008 |
| Cdc42 | HSC/niche | Yang et al. PNAS 2007 |
| Ang-1/Tie2 | Quiescence | Arai et al. Cell 2004 |
| TPO/MPL | Quiescence | Qian et al. Cell Stem Cell 2007; Yoshihara et al. Cell Stem Cell 2007 |
| PTEN | Self-renewal and quiescence | Zhang et al. Nature 2006; Yilmaz et al. Nature 2006 |
| GSK-3 | HSC maintenance | Trowbridge et al. Nat Med. 2006 |
| LNK | Self-renewal | Seita et al. PNAS 2007 |
| Notch | Self-renewal | Duncan et al. Nature Immunol 2005 |
| Wnt signaling | Self-renewal | Reya et al. Nature 2003 |
| Hedgehog | Self-renewal | Trowbridge et al. PNAS 2006 |
| Zfz | Self-renewal | Galan-Caridad et al. Cell 2007 |