Indications for diagnostic tests.
| Test . | Indication . |
|---|---|
| Physical exam | Diagnosis/staging Every 3-month until resolution of splenomegaly Suspected progression or resistance |
| Complete blood count | Diagnosis/staging Every 1–2 weeks until blood counts have stabilized, then at 6 weeks intervals Suspected progression or resistance |
| Bone marrow metaphase karyotyping | Diagnosis/staging 6, 12, 18 months or until complete cytogenetic response Suspected progression or resistance |
| Quantitative PCR for BCR-ABL | Every 3 months once CCyR documented |
| FISH for BCR-ABL (peripheral blood) | Uncertain diagnosis (typical clinical presentation, but metaphase cytogenetics not successful or Philadelphia-chromosome negative) Every 3 months if no access to high quality quantitative PCR monitoring |
| Qualitative (low sensitivity) PCR for BCR-ABL | Uncertain diagnosis (typical clinical presentation, but metaphase cytogenetics not successful or Philadelphia-chromosome negative) |
| BCR-ABL kinase mutation screen | Suspected progression or resistance |
| Test . | Indication . |
|---|---|
| Physical exam | Diagnosis/staging Every 3-month until resolution of splenomegaly Suspected progression or resistance |
| Complete blood count | Diagnosis/staging Every 1–2 weeks until blood counts have stabilized, then at 6 weeks intervals Suspected progression or resistance |
| Bone marrow metaphase karyotyping | Diagnosis/staging 6, 12, 18 months or until complete cytogenetic response Suspected progression or resistance |
| Quantitative PCR for BCR-ABL | Every 3 months once CCyR documented |
| FISH for BCR-ABL (peripheral blood) | Uncertain diagnosis (typical clinical presentation, but metaphase cytogenetics not successful or Philadelphia-chromosome negative) Every 3 months if no access to high quality quantitative PCR monitoring |
| Qualitative (low sensitivity) PCR for BCR-ABL | Uncertain diagnosis (typical clinical presentation, but metaphase cytogenetics not successful or Philadelphia-chromosome negative) |
| BCR-ABL kinase mutation screen | Suspected progression or resistance |