Criteria for defining risk groups in stages I/II Hodgkin lymphoma.
| Trial group . | Risk group . | Criteria . |
|---|---|---|
| EORTC | Favorable | One or two nodal areas and |
| No mediastinal bulk (mass > 0.35 of thoracic diameter at level of D5-6) and | ||
| In the prescence of B symptoms, ESR < 30 | ||
| or in the absence of B symptoms, ESR < 50 | ||
| Unfavorable | Any of the above risk factors present | |
| GHSG | Favorable | One or two nodal areas and |
| No mediastinal bulk and | ||
| No extra-nodal disease and | ||
| In the prescence of B symptoms, ESR < 30 | ||
| or in the absence of B symptoms, ESR < 50 | ||
| Age 75 years or less | ||
| Unfavorable | Any of the above risk factors present | |
| NCI (Canada) and ECOG | Exclude high risk | Bulky mediastinal involvement or |
| Intra-abdominal disease | ||
| Exclude low risk | Stage IA with single node involved in high neck or epitrochlear regions only and | |
| Lymphocyte predominant or nodular sclerosing histology and | ||
| Bulk < 3 cm and | ||
| ESR < 50 | ||
| Remainder categorized as favorable or unfavorable. | ||
| Unfavorable patients have any of | Age ≥ 40 | |
| ESR ≥ 50 | ||
| Mixed cellularity or lymphocyte-depleted histology | ||
| ≥ 4 sites of disease |
| Trial group . | Risk group . | Criteria . |
|---|---|---|
| EORTC | Favorable | One or two nodal areas and |
| No mediastinal bulk (mass > 0.35 of thoracic diameter at level of D5-6) and | ||
| In the prescence of B symptoms, ESR < 30 | ||
| or in the absence of B symptoms, ESR < 50 | ||
| Unfavorable | Any of the above risk factors present | |
| GHSG | Favorable | One or two nodal areas and |
| No mediastinal bulk and | ||
| No extra-nodal disease and | ||
| In the prescence of B symptoms, ESR < 30 | ||
| or in the absence of B symptoms, ESR < 50 | ||
| Age 75 years or less | ||
| Unfavorable | Any of the above risk factors present | |
| NCI (Canada) and ECOG | Exclude high risk | Bulky mediastinal involvement or |
| Intra-abdominal disease | ||
| Exclude low risk | Stage IA with single node involved in high neck or epitrochlear regions only and | |
| Lymphocyte predominant or nodular sclerosing histology and | ||
| Bulk < 3 cm and | ||
| ESR < 50 | ||
| Remainder categorized as favorable or unfavorable. | ||
| Unfavorable patients have any of | Age ≥ 40 | |
| ESR ≥ 50 | ||
| Mixed cellularity or lymphocyte-depleted histology | ||
| ≥ 4 sites of disease |