Genes whose expression was associated with drug resistance in ALL in more than one study.
| Probe set ID* . | Gene name . | Gene symbol . | Main biological processes . | References† . |
|---|---|---|---|---|
| *In Affymetrix U133 GeneChip | ||||
| †References in which gene expression was associated with MRD or drug sensitivity in vitro | ||||
| Genes overexpressed in cases with drug resistance in vitro or in vivo | ||||
| 201376_s_at | Heterogeneous nuclear ribonucleoprotein F | HNRPF | RNA processing | 18, 23 |
| 205644_s_at | Small nuclear ribonucleoprotein polypeptide G | SNRPG | Spliceosome assembly, mRNA processing | 17, 23 |
| 208808_s_at | High-mobility group box 2 | HMGB2 | DNA replication, DNA repair, nucleosome assembly, regulation of transcription, phosphoinositide-mediated signaling | 18, 23 |
| 209760_at | KIAA0922 | KIAA0922 | 17, 23 | |
| 213911_s_at | H2A histone family, member Z | H2AFZ | Nucleosome assembly | 18, 23 |
| 218381_s_at | Sphingosine-1-phosphate lyase 1 | SGPL1 | Lipid metabolism, ceramide metabolism, apoptosis | 17, 23 |
| 218802_at | Coiled-coil domain containing 109B | CCDC109B | 17, 18, 23 | |
| Genes underexpressed in cases with drug resistance in vitro or in vivo | ||||
| 38710_at | OTU domain, ubiquitin aldehyde binding 1 | OTUB1 | Ubiquitin cycle | 17, 23 |
| 201088_at | Karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | KPNA2 | DNA recombination, microtubule process, cell cycle, protein import into nucleus | 17, 23, 17, 23 |
| 201694_s_at | Early growth response 1 | EGR1 | Regulation of transcription | 17, 23 |
| 201755_at | Minichromosome maintenance complex component 5 | MCM5 | DNA replication, regulation of transcription | 21, 23 |
| 201897_s_at | CDC28 protein kinase regulatory subunit 1B | CKS1B | Cell cycle | 17, 23 |
| 202499_s_at | solute carrier family 2, member 3 | SLC2A3 | Carbohydrate metabolism, transport | 18, 23 |
| 203362_s_at | MAD2 mitotic arrest deficient-like 1 (yeast) | MAD2L1 | Cell cycle | 21, 23 |
| 204822_at | TTK protein kinase | TTK | Protein phosphorylation, mitotic spindle organization, cell proliferation | 21, 22 |
| 205193_at | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) | MAFF | Regulation of transcription | 18, 23 |
| 209795_at | CD69 | CD69 | Signal transduction | 18, 23 |
| Probe set ID* . | Gene name . | Gene symbol . | Main biological processes . | References† . |
|---|---|---|---|---|
| *In Affymetrix U133 GeneChip | ||||
| †References in which gene expression was associated with MRD or drug sensitivity in vitro | ||||
| Genes overexpressed in cases with drug resistance in vitro or in vivo | ||||
| 201376_s_at | Heterogeneous nuclear ribonucleoprotein F | HNRPF | RNA processing | 18, 23 |
| 205644_s_at | Small nuclear ribonucleoprotein polypeptide G | SNRPG | Spliceosome assembly, mRNA processing | 17, 23 |
| 208808_s_at | High-mobility group box 2 | HMGB2 | DNA replication, DNA repair, nucleosome assembly, regulation of transcription, phosphoinositide-mediated signaling | 18, 23 |
| 209760_at | KIAA0922 | KIAA0922 | 17, 23 | |
| 213911_s_at | H2A histone family, member Z | H2AFZ | Nucleosome assembly | 18, 23 |
| 218381_s_at | Sphingosine-1-phosphate lyase 1 | SGPL1 | Lipid metabolism, ceramide metabolism, apoptosis | 17, 23 |
| 218802_at | Coiled-coil domain containing 109B | CCDC109B | 17, 18, 23 | |
| Genes underexpressed in cases with drug resistance in vitro or in vivo | ||||
| 38710_at | OTU domain, ubiquitin aldehyde binding 1 | OTUB1 | Ubiquitin cycle | 17, 23 |
| 201088_at | Karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | KPNA2 | DNA recombination, microtubule process, cell cycle, protein import into nucleus | 17, 23, 17, 23 |
| 201694_s_at | Early growth response 1 | EGR1 | Regulation of transcription | 17, 23 |
| 201755_at | Minichromosome maintenance complex component 5 | MCM5 | DNA replication, regulation of transcription | 21, 23 |
| 201897_s_at | CDC28 protein kinase regulatory subunit 1B | CKS1B | Cell cycle | 17, 23 |
| 202499_s_at | solute carrier family 2, member 3 | SLC2A3 | Carbohydrate metabolism, transport | 18, 23 |
| 203362_s_at | MAD2 mitotic arrest deficient-like 1 (yeast) | MAD2L1 | Cell cycle | 21, 23 |
| 204822_at | TTK protein kinase | TTK | Protein phosphorylation, mitotic spindle organization, cell proliferation | 21, 22 |
| 205193_at | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) | MAFF | Regulation of transcription | 18, 23 |
| 209795_at | CD69 | CD69 | Signal transduction | 18, 23 |