Recommended screening practices for pulmonary, cardiac, cardiovascular and renal late complications after hematopoietic stem cell transplantation (HSCT).
| Organ . | Baseline assessment . | Long-term monitoring . |
|---|---|---|
| Respiratory tract | Mandatory in all patients: History of respiratory tract disease Smoking habits Clinical assessment Pulmonary function Chest X-ray | Regular visits (6 mo; annual): History of respiratory track disease and smoking habits since last visit Clinical assessment, inclusively of chronic GvHD in other organs Pulmonary function testing (allo HSCT) |
| In patients at risk: High-resolution CT | If indicated (one or several): Chest X-ray High-resoultion CT Bronchoalveolar lavage Biopsy | |
| Heart and cardiovascular system | Mandatory in all patients: History of cardiac and vascular disease History of cardiovascular risk factors (smoking, familiar risk, hypertension, life style) Exposure to anthracyclines, radiation therapy Clinical assessment Electrocardiogram | Regular visits (annual): History of cardiac and cardiovascular disease since last visit Exposure since last visit (smoking life style) Therapy for cardiovascular risk factors since last visit Clinical assessment Cardiovascular risk factors |
| Patients at risk: Echocardiography 24-hour electrocardiogram Additional functional tests | If indicated (one or several): ECG Echocardiography 24-hour electrocardiogram Radiological and echocardiographic assessment of vascular disease Additional functional tests | |
| Kidney | Mandatory in all patients: History of renal disease Clinical assessment BUN and creatinine GFR Urine protein | Regular visits (6 mo; annual): History of kidney disease and treatment of hypertension since last visit BUN and creatinine GFR Urine protein |
| If indicated: Renal biopsy |
| Organ . | Baseline assessment . | Long-term monitoring . |
|---|---|---|
| Respiratory tract | Mandatory in all patients: History of respiratory tract disease Smoking habits Clinical assessment Pulmonary function Chest X-ray | Regular visits (6 mo; annual): History of respiratory track disease and smoking habits since last visit Clinical assessment, inclusively of chronic GvHD in other organs Pulmonary function testing (allo HSCT) |
| In patients at risk: High-resolution CT | If indicated (one or several): Chest X-ray High-resoultion CT Bronchoalveolar lavage Biopsy | |
| Heart and cardiovascular system | Mandatory in all patients: History of cardiac and vascular disease History of cardiovascular risk factors (smoking, familiar risk, hypertension, life style) Exposure to anthracyclines, radiation therapy Clinical assessment Electrocardiogram | Regular visits (annual): History of cardiac and cardiovascular disease since last visit Exposure since last visit (smoking life style) Therapy for cardiovascular risk factors since last visit Clinical assessment Cardiovascular risk factors |
| Patients at risk: Echocardiography 24-hour electrocardiogram Additional functional tests | If indicated (one or several): ECG Echocardiography 24-hour electrocardiogram Radiological and echocardiographic assessment of vascular disease Additional functional tests | |
| Kidney | Mandatory in all patients: History of renal disease Clinical assessment BUN and creatinine GFR Urine protein | Regular visits (6 mo; annual): History of kidney disease and treatment of hypertension since last visit BUN and creatinine GFR Urine protein |
| If indicated: Renal biopsy |