Hematological characteristics of male and female HbSS mice
| . | Male HbSS . | Female HbSS . | ||||||
|---|---|---|---|---|---|---|---|---|
| 8 wk of age . | 12 wk of age . | 20 wk of age . | 32 wk of age . | 8 wk of age . | 12 wk of age . | 20 wk of age . | 32 wk of age . | |
| Hb, g/dL | 6.9 ± 0.9 | 6.2 ± 0.7 | 9.4 ± 0.5 | 6.5 ± 0.6 | 6.1 ± 0.2 | 9.4 ± 0.3* | 5.7 ± 0 | 8.4 ± 0.6 |
| Ht, % | 33.7 ± 4.2 | 21.2 ± 2.0 | 30.0 ± 1.3 | 22.5 ± 1.9 | 24.4 ± 1.0 | 35.7 ± 1.9* | 23.6 ± 0 | 31.4 ± 1.0 |
| RBC, ×1012/L | 5.7 ± 0.4 | 4.2 ± 0.4 | 6.1 ± 0.5 | 4.5 ± 0.2 | 4.5 ± 0.2 | 6.0 ± 0.3* | 4.5 ± 0 | 6.7 ± 0.2* |
| MCV, fL | 47.3 ± 3.3 | 50.6 ± 4.2 | 49.8 ± 2.9 | 49.6 ± 3.6 | 53.9 ± 1.6 | 59.6 ± 1.8 | 52.8 ± 0 | 47.6 ± 0.3 |
| MCH, pg | 10.1 ± 2.7 | 14.6 ± 1.2 | 15.5 ± 0.6 | 14.5 ± 1.2 | 13.6 ± 0.9 | 15.9 ± 0.5 | 13.0 ± 0 | 12.6 ± 0.4 |
| MCHC, g/dL | 20.2 ± 4.8 | 28.9 ± 0.7 | 31.2 ± 0.9 | 29.0 ± 0.4 | 25.0 ± 0.9 | 26.9 ± 1.4 | 24.6 ± 0 | 26.3 ± 0.7 |
| RDW, % | 33.4 ± 1.0 | 31.3 ± 2.1 | 31.7 ± 2.8 | 28.1 ± 1.6 | 31.0 ± 1.7 | 29.6 ± 0.8 | 27.0 ± 0 | 32.7 ± 2.0 |
| WBC, ×109/L | 27.9 ± 8.2 | 27.8 ± 9.6 | 39.5 ± 9.1 | 30.4 ± 4.6 | 30.0 ± 4.4 | 49.5 ± 5.5 | 12.2 ± 0 | 39.1 ± 4.9 |
| PLT, ×109/L | 992 ± 119 | 637 ± 90 | 1042 ± 89 | 802 ± 102 | 556 ± 45* | 658 ± 68 | 438 ± 0 | 1083 ± 51 |
| . | Male HbSS . | Female HbSS . | ||||||
|---|---|---|---|---|---|---|---|---|
| 8 wk of age . | 12 wk of age . | 20 wk of age . | 32 wk of age . | 8 wk of age . | 12 wk of age . | 20 wk of age . | 32 wk of age . | |
| Hb, g/dL | 6.9 ± 0.9 | 6.2 ± 0.7 | 9.4 ± 0.5 | 6.5 ± 0.6 | 6.1 ± 0.2 | 9.4 ± 0.3* | 5.7 ± 0 | 8.4 ± 0.6 |
| Ht, % | 33.7 ± 4.2 | 21.2 ± 2.0 | 30.0 ± 1.3 | 22.5 ± 1.9 | 24.4 ± 1.0 | 35.7 ± 1.9* | 23.6 ± 0 | 31.4 ± 1.0 |
| RBC, ×1012/L | 5.7 ± 0.4 | 4.2 ± 0.4 | 6.1 ± 0.5 | 4.5 ± 0.2 | 4.5 ± 0.2 | 6.0 ± 0.3* | 4.5 ± 0 | 6.7 ± 0.2* |
| MCV, fL | 47.3 ± 3.3 | 50.6 ± 4.2 | 49.8 ± 2.9 | 49.6 ± 3.6 | 53.9 ± 1.6 | 59.6 ± 1.8 | 52.8 ± 0 | 47.6 ± 0.3 |
| MCH, pg | 10.1 ± 2.7 | 14.6 ± 1.2 | 15.5 ± 0.6 | 14.5 ± 1.2 | 13.6 ± 0.9 | 15.9 ± 0.5 | 13.0 ± 0 | 12.6 ± 0.4 |
| MCHC, g/dL | 20.2 ± 4.8 | 28.9 ± 0.7 | 31.2 ± 0.9 | 29.0 ± 0.4 | 25.0 ± 0.9 | 26.9 ± 1.4 | 24.6 ± 0 | 26.3 ± 0.7 |
| RDW, % | 33.4 ± 1.0 | 31.3 ± 2.1 | 31.7 ± 2.8 | 28.1 ± 1.6 | 31.0 ± 1.7 | 29.6 ± 0.8 | 27.0 ± 0 | 32.7 ± 2.0 |
| WBC, ×109/L | 27.9 ± 8.2 | 27.8 ± 9.6 | 39.5 ± 9.1 | 30.4 ± 4.6 | 30.0 ± 4.4 | 49.5 ± 5.5 | 12.2 ± 0 | 39.1 ± 4.9 |
| PLT, ×109/L | 992 ± 119 | 637 ± 90 | 1042 ± 89 | 802 ± 102 | 556 ± 45* | 658 ± 68 | 438 ± 0 | 1083 ± 51 |
Data are means ± SEM (n = 4-5 in each HbSS groups).
Hb, hemoglobin; Ht, hematocrit; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; PLT, platelet; RBC, red blood cell; RDW, red cell distribution width; WBC, white blood cell.
P < .05 vs age-matched male HbSS.