Inherent immune defects in patients with chronic lymphocytic leukemia (CLL).
| Hypogammaglobulinemia |
| Inhibition in B-cell proliferation |
| Cell-mediated immune defects |
| Functional abnormalities of T-lymphocytes, nonclonal CD5− B-lymphocytes |
| Abnormalities in T-cell subsets, with a decreased CD4/CD8 ratio |
| Excessive T-suppressor and deficient T-helper cell function |
| Downregulated T-cell function |
| Defects in NK-cell, lymphocyte-activated killer cell activity |
| Reduced T-cell colony-forming capacity |
| Defective antibody-dependent cytotoxicity |
| Defective delayed hypersensitivity responses |
| Defects in complement activity |
| Reduction in complement component levels |
| Defects in complement activation and binding |
| Neutrophil defects |
| Defects in neutrophil function (phagocytic, bactericidal activity, chemotaxis) |
| Reduced absolute neutrophil count |
| Monocyte defects (deficiencies in β-glucuronidase, lysozyme, myeloperoxidase) |
| Potential mucosal immune defects |
| Hypogammaglobulinemia |
| Inhibition in B-cell proliferation |
| Cell-mediated immune defects |
| Functional abnormalities of T-lymphocytes, nonclonal CD5− B-lymphocytes |
| Abnormalities in T-cell subsets, with a decreased CD4/CD8 ratio |
| Excessive T-suppressor and deficient T-helper cell function |
| Downregulated T-cell function |
| Defects in NK-cell, lymphocyte-activated killer cell activity |
| Reduced T-cell colony-forming capacity |
| Defective antibody-dependent cytotoxicity |
| Defective delayed hypersensitivity responses |
| Defects in complement activity |
| Reduction in complement component levels |
| Defects in complement activation and binding |
| Neutrophil defects |
| Defects in neutrophil function (phagocytic, bactericidal activity, chemotaxis) |
| Reduced absolute neutrophil count |
| Monocyte defects (deficiencies in β-glucuronidase, lysozyme, myeloperoxidase) |
| Potential mucosal immune defects |