Acquired or secondary thrombophilia.
| Strongly Supportive Data |
| Active cancer |
| Chemotherapy (L-asparaginase, thalidomide, anti-angiogenesis therapy) |
| Myeloproliferative disorders |
| Heparin-induced thrombocytopenia |
| Nephrotic syndrome |
| Intravascular coagulation and fibrinolysis/disseminated intravascular coagulation |
| Thrombotic thrombocytopenic purpura |
| Sickle cell disease |
| Oral contraceptives |
| Estrogen therapy |
| Pregnancy/postpartum state |
| Selective estrogen receptor modulator therapy (tamoxifen and raloxifene) |
| Antiphospholipid antibodies (lupus anticoagulant, |
| anticardiolipin antibody, anti-β2 glycoprotein-1 antibody) |
| Paroxysmal nocturnal hemoglobinuria |
| Wegener granulomatosis |
| Supportive Data |
| Inflammatory bowel disease |
| Thromboangiitis obliterans (Buerger disease) |
| Behçet syndrome |
| Varicose veins |
| Systemic lupus erythematosus |
| Venous vascular anomalies (e.g., Klippel Trenaunay syndrome) |
| Progesterone therapy |
| Infertility “therapy” |
| Hyperhomocysteinemia |
| HIV infection |
| Dehydration |
| Strongly Supportive Data |
| Active cancer |
| Chemotherapy (L-asparaginase, thalidomide, anti-angiogenesis therapy) |
| Myeloproliferative disorders |
| Heparin-induced thrombocytopenia |
| Nephrotic syndrome |
| Intravascular coagulation and fibrinolysis/disseminated intravascular coagulation |
| Thrombotic thrombocytopenic purpura |
| Sickle cell disease |
| Oral contraceptives |
| Estrogen therapy |
| Pregnancy/postpartum state |
| Selective estrogen receptor modulator therapy (tamoxifen and raloxifene) |
| Antiphospholipid antibodies (lupus anticoagulant, |
| anticardiolipin antibody, anti-β2 glycoprotein-1 antibody) |
| Paroxysmal nocturnal hemoglobinuria |
| Wegener granulomatosis |
| Supportive Data |
| Inflammatory bowel disease |
| Thromboangiitis obliterans (Buerger disease) |
| Behçet syndrome |
| Varicose veins |
| Systemic lupus erythematosus |
| Venous vascular anomalies (e.g., Klippel Trenaunay syndrome) |
| Progesterone therapy |
| Infertility “therapy” |
| Hyperhomocysteinemia |
| HIV infection |
| Dehydration |