Table 1. Molecular genetics of... | American Society of Hematology

Table 1.

Molecular genetics of thrombohemorrhagic syndromes associated with human tumors.

Oncogene/tumor suppressor gene	Signaling pathway	Tumor	Vascular outcome	Gene products regulated
Abbreviations: DIC, disseminated intravascular coagulation; PAI-1, plasminogen activator inhibitor type 1; COX-2, cyclooxygenase type 2; TF, tissue factor; VEGF, vascular endothelial growth factor; TSP, thrombospondin.
Modified from Rickles⁴³ with permission of the publisher.
MET	Tyrosine kinase receptor	Hepatoma	Thrombosis; DIC	PAI-1, COX-2
PTEN	MEK/ERK	Glioblastoma	Thrombosis; necrosis	TF
K-ras; p53	MEK/MAPK/PI3K	Colon cancer	Tumor angiogenesis	TF, VEGF, TSP

Oncogene/tumor suppressor gene	Signaling pathway	Tumor	Vascular outcome	Gene products regulated
Abbreviations: DIC, disseminated intravascular coagulation; PAI-1, plasminogen activator inhibitor type 1; COX-2, cyclooxygenase type 2; TF, tissue factor; VEGF, vascular endothelial growth factor; TSP, thrombospondin.
Modified from Rickles⁴³ with permission of the publisher.
MET	Tyrosine kinase receptor	Hepatoma	Thrombosis; DIC	PAI-1, COX-2
PTEN	MEK/ERK	Glioblastoma	Thrombosis; necrosis	TF
K-ras; p53	MEK/MAPK/PI3K	Colon cancer	Tumor angiogenesis	TF, VEGF, TSP