Table 1. Factors that culminate in... | American Society of Hematology

Table 1.

Factors that culminate in vaso-occlusion in patients with sickle cell disease.

Factors intrinsic to red blood cells (RBCs)

Sickle hemoglobin polymerization
Rheology of sickle RBCs
- Cellular dehydration
- RBC deformability and mechanical fragility
- Dense cells

Factors extrinsic to red blood cells

Whole blood viscosity
White blood cell factors
Endothelial factors
- Adhesion of sickle RBCs to endothelium
- Intimal hyperplasia
Hemostatic factors
Vascular factors