Examples of candidate antigens in B-cell malignancies.
| Antigen class . | Putative functional role . | Phenotype of effector cells . |
|---|---|---|
| Immunoglobulin idiotype | Antigen receptor | CD4 and CD8 |
| Overexpressed proteins | ||
| Bcl-2 | Antiapoptotic | CD8 |
| Survivin | Antiapoptotic | CD8 |
| hdm2 | Antiapoptotic, growth control | CD8 |
| Fibromodulin | Collagen-binding protein | CD8 |
| Oncofetal antigen immature laminin receptor | Integrin binding | CD8 |
| Viral antigens | ||
| EBV-EBNA-1 | Viral latency and cellular gene transcription | CD4 |
| EBV-LMP-2 | Promotes cell survival | CD4 and CD8 |
| Minor histocompatibility antigens | ||
| HA-1 | Unknown | CD8 |
| HB-1 | Unknown | CD8 |
| PANE-1 | Unknown | CD8 |
| Bcl2A1 | Antiapoptotic | CD8 |
| P2X5 | Purinergic receptor | CD8 |
| Antigen class . | Putative functional role . | Phenotype of effector cells . |
|---|---|---|
| Immunoglobulin idiotype | Antigen receptor | CD4 and CD8 |
| Overexpressed proteins | ||
| Bcl-2 | Antiapoptotic | CD8 |
| Survivin | Antiapoptotic | CD8 |
| hdm2 | Antiapoptotic, growth control | CD8 |
| Fibromodulin | Collagen-binding protein | CD8 |
| Oncofetal antigen immature laminin receptor | Integrin binding | CD8 |
| Viral antigens | ||
| EBV-EBNA-1 | Viral latency and cellular gene transcription | CD4 |
| EBV-LMP-2 | Promotes cell survival | CD4 and CD8 |
| Minor histocompatibility antigens | ||
| HA-1 | Unknown | CD8 |
| HB-1 | Unknown | CD8 |
| PANE-1 | Unknown | CD8 |
| Bcl2A1 | Antiapoptotic | CD8 |
| P2X5 | Purinergic receptor | CD8 |