| PET scan acquisition and interpretation | Consensus versus standard reading Use of other clinical information Adjudication of conflicts Minimal residual uptake Visual versus SUV versus rate of change Technical: equipment, recording Inexperienced readers Factoring likelihood of false positives and negatives
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| Escalation of therapy | Not known to be effective Early PET-positive may also predict failure of intensive therapy Not an option for elderly
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| De-escalation of therapy | |
| Study design and conduct | Assumptions made on clinical risk Assumptions made on efficacy of cross-over design Necessity for blinding Equipoise for patients and physicians based on published and presented results
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