Table 2. Combination chemotherapy—recent... | American Society of Hematology

Table 2.

Combination chemotherapy—recent randomized trials comparing fludarabine plus cyclophosphamide versus fludarabine.

Reference	Regimen	N	Median age, y	Advanced stage, %*	ANC, toxicity grade 3–4, %	CR, %	OR, %	PFS, mo
*Rai III-IV
**Binet C
F indicates fludarabine; Clb, chlorambucil; C, cyclophosphamide; ANC, absolute neutrophil count.
Catovsky²²	Clb	387	65	31	28	7	72	20
	F	194	64	29	41	15	80	23
	FC	196	65	30	56	38	94	43
Flinn²¹	F	137	61	42	63	5	59	19
	FC	141	61	44	69	23	74	32
Eichhorst⁶²	F	182	59	41	26	7	83	20
	FC	180	58	39	56	24	95	48

Reference	Regimen	N	Median age, y	Advanced stage, %*	ANC, toxicity grade 3–4, %	CR, %	OR, %	PFS, mo
*Rai III-IV
**Binet C
F indicates fludarabine; Clb, chlorambucil; C, cyclophosphamide; ANC, absolute neutrophil count.
Catovsky²²	Clb	387	65	31	28	7	72	20
	F	194	64	29	41	15	80	23
	FC	196	65	30	56	38	94	43
Flinn²¹	F	137	61	42	63	5	59	19
	FC	141	61	44	69	23	74	32
Eichhorst⁶²	F	182	59	41	26	7	83	20
	FC	180	58	39	56	24	95	48