Prevalence of CLL-type monoclonal B-cell lymphocytosis (MBL) in population studies. The detected prevalence is highly dependent on the method of detection.
| Study Group . | Flow Cytometry . | CLL-type MBL Prevalence . | ||||||
|---|---|---|---|---|---|---|---|---|
| Source . | Median age, y (range) . | n . | No. of colors . | CD19/5 + κ/λ . | CD19/5 + CD20 . | Events × 103 . | All ages in study, % . | CLL-type MBL > 60 y, % . |
| *Estimated from data. | ||||||||
| †Age above 65 years. | ||||||||
| ‡Age range 60–80 years. | ||||||||
| U.S. residential population23 | 53 (40–78) | 1926 | 2 | No | No | N.S. | 0.6 | >0.6* |
| U.S. blood donors28 | 45 (18–79) | 5141 | 2 | No | No | N.S. | 0.14 | 0.9 |
| U.K. hospital outpatients21 | 57 (40–90) | 910 | 4 | Yes | Yes | 200 | 3.5 | 5.0 |
| Italy primary care25 | 74 (65–98) | 500 | 4 | Yes | Yes | 200 | 5.5 | 5.5† |
| U.K. hospital outpatients21 | 74 (60–80) | 1520 | 4 | Yes | No | 200 | 5.1 | 5.1‡ |
| Italy residential population26 | 55 (18–102) | 1725 | 5 | Yes | Yes | 500 | 7.4 | 8.9 |
| Spain primary care27 | 62 (40–97) | 608 | 8 | Yes | Yes | 5000 | 12.0 | >20* |
| Study Group . | Flow Cytometry . | CLL-type MBL Prevalence . | ||||||
|---|---|---|---|---|---|---|---|---|
| Source . | Median age, y (range) . | n . | No. of colors . | CD19/5 + κ/λ . | CD19/5 + CD20 . | Events × 103 . | All ages in study, % . | CLL-type MBL > 60 y, % . |
| *Estimated from data. | ||||||||
| †Age above 65 years. | ||||||||
| ‡Age range 60–80 years. | ||||||||
| U.S. residential population23 | 53 (40–78) | 1926 | 2 | No | No | N.S. | 0.6 | >0.6* |
| U.S. blood donors28 | 45 (18–79) | 5141 | 2 | No | No | N.S. | 0.14 | 0.9 |
| U.K. hospital outpatients21 | 57 (40–90) | 910 | 4 | Yes | Yes | 200 | 3.5 | 5.0 |
| Italy primary care25 | 74 (65–98) | 500 | 4 | Yes | Yes | 200 | 5.5 | 5.5† |
| U.K. hospital outpatients21 | 74 (60–80) | 1520 | 4 | Yes | No | 200 | 5.1 | 5.1‡ |
| Italy residential population26 | 55 (18–102) | 1725 | 5 | Yes | Yes | 500 | 7.4 | 8.9 |
| Spain primary care27 | 62 (40–97) | 608 | 8 | Yes | Yes | 5000 | 12.0 | >20* |